| CELLULAR IMMUNITY EFFECT OF LEUKEMIA VACCINE ON TUMOR BURDEN RAT |
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| 作者姓名： | 赵万红 张王刚 何爱丽 王一理 耿宜萍 田玮 宋长锁 |
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| 作者单位： | Department of Hematology，Department of Hematology，Department of Hematology，Institute of Immunopathology，Institute of Immunopathology，Department of Hematology，Department of Hematology Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Medical School of Xi’an Jiaotong University，Xi’an 710061，China，Medical School of Xi’an Jiaotong University，Xi’an 710061，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China，Second Hospital of Xi'an Jiaotong University，Xi'an 710004，China |
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| 基金项目： | ThisworkwassupportedbytheKeyClinicDepartmentDevelopmentItemofChina ,HealthMinistry(No.3 2 0205IM35A)andScientificResearchFoundationoftheSecondHospitalofXi’anJiaotongUniversity(No .2 0 0 0KY 0 4) |
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| 摘 要： | Atpresent ,chemotherapyisstillimportanttotreatthemalignanthematopoitictumor .Thisthera pyhasnotonlymanysideeffectsbutalsoitssurviv alrateisverylow .Now ,theresearchofactivespe cificimmunotherapyhasbecomearesearchhotspotaftertheprogressofmolecules immunologyandtu mor immunology .Ithasbeenacceptedasanewwaytotreattheleukemiainthe 4 2 ndAmericaHema tologyMeeting .Sotheimmunotherapyofleukemiahasbeenverynoticing .Onthebasisofsometreat menteffectsontreatingsomeleukemia patientswithourleukemiavaccin…
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CELLULAR IMMUNITY EFFECT OF LEUKEMIA VACCINE ON TUMOR BURDEN RAT |
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| Zhao Wanhong,Zhang Wanggang,He Aili,Wang Yili ,Geng Yiping ,Tian Wei,Song Changsuo.CELLULAR IMMUNITY EFFECT OF LEUKEMIA VACCINE ON TUMOR BURDEN RAT[J].Academic Journal of Xi’an Jiaotong University,2003,15(1). |
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| Authors: | Zhao Wanhong Zhang Wanggang He Aili Wang Yili Geng Yiping Tian Wei Song Changsuo |
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| Institution: | 1. Department of Hematology , Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China
2. Institute of Immunopathology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China |
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| Abstract: | Objective To evaluate the effect of the active specific immunotherapy with leukemia vaccine in the malignant hematopoietic diseases. Methods We established the animal models by inoculating C57BL/6 rats with FBL-3 erythroleukemia cells and prepared three types of tumor vaccine, which were administered on the rats respectively. The MTT colorimetric assay was adopted 2 and 4 weeks later to test the cytotoxicity of macrophage(MΦ) and that of cytotoxic T lymphocyte(CTL) derived from the rats injected with tumor vaccines, and compared the results with the control group. Results With the growth of erythroleulemia cells in the rats, the cellular immunity was seriously depressed, and the inhibition of specific cellular immunity was later than that of non-specific cellular immunity. The tumor vaccine made from inactivated tumor cells, IFA and cytokines (rGM-CSF, rIL-2 and rIL-6), promote the cellular immunity of tumor burden rats, especially the specific cellular immunity more efficiently than that of tumor vaccine made from inactivated tumor cells and IFA, but the third vaccine made from inactivated tumor cells alone has no effect. Conclusion The tumor vaccine made from inactivated tumor cells with addition of IFA and cytokines (rGM-CSF, rIL-2 and rIL-6) provides a promising future in the active specific immunotherapy against hematopoietic tumor. |
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| Keywords: | active specific immunotherapy leukemia tumor vaccine macrophage cytotoxicity T lymphocyte |
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