国产透明质酸钠治疗膝关节退行性关节病的对照研究

目的　通过临床随机对照研究检验国产透明质酸钠治疗膝关节退行性关节病的效果及不良反应 ,为该病治疗寻找新的途径。方法　应用临床随机对照方法将患者分成治疗组与对照组 ,治疗组应用透明质酸钠 ,对照组应用醋酸强的松龙 ,均行膝关节腔注射 ,每周 1次 ,每次剂量分别为 2 0mg和 75mg ,5次为一个疗程 ,治疗前、后观察临床症状及检测关节滑液中白细胞介素 6 (IL 6 )水平及蛋白总量的变化。结果　两种药物均可有效缓解膝关节退行性关节病的临床症状 ,治疗组显效率 5 2 .78% ,有效率 4 4 .4 4 % ,无效率 2 .86 % ;对照组显效率 39.2 9% ,有效率 4 2 .86 % ,无效率 17.86 %。两种药物均可显著降低关节滑液内IL 6的含量 ,但治疗组降低幅度更大。结论　应用透明质酸钠治疗膝关节退行性关节病疗效明显 ,无严重不良反应。

Randomized controlled trial of sodium hyaluronate for degenerative disorders of the knee joint

Objective To assess the effect of sodium hyaluromate (HA) on degenerative disorders of the knee joint (KJ). Methods A prospective randomized controlled clinical trial was conducted. The experimental group received injections in the compartments of the involved KJ with 1% HA 20mg, whereas the control group received prednisolone (PS) of 75mg once a week with five injections as one course. One week before and after the treatment , clinical symptoms, amount of interleukin-6 (IL-6) and total protein of synovial fluid were measured and compared. Results Both drugs could relieve the clinical symptoms of KJ degenerative disorders. In HA group, marked improvement rate was 52.78% and failure rate was 2.86%, whereas marked improvement rate was 39.29% and failure rate 17.86% in PS group. The declined levels of IL-6 in synovial fluid were notably greater in HA group than those in PS group. Conclusion Intra-articular injection of HA is effective and safe in treating KJ dgenerative disorders with mild adverse reactions.