高危尿毒症患者肾移植术后早期全血环孢素A浓度的监测及临床意义

探讨不同高危患者术后应用 Cs A免疫抑制治疗的特点 ,摸索高危患者肾移植术后的早期临床监测及处理。方法　应用荧光偏振免疫法 ( FPIA)对 30例高危尿毒症患者肾移植术后早期的全血环孢素 A( Cs A)浓度进行动态监测。结果　高危尿毒症患者肾移植术后早期的全血 Cs A浓度明显高于对照组 ,术后早期急性排斥反应的发生率低 ,但是容易发生 Cs A的肝脏及胰腺的毒副作用。结论　早期动态监测全血 Cs A浓度有助于预防和减轻 Cs A的毒副作用 ,维持有效的免疫抑制治疗

Monitoring CsA whole blood concentration of high risk uremia in the early stage of post renal transplantation

Objective To study the characters of CsA immunosuppressive treatment at the early stage of post transplantation among different high risk uremia.Methods The CsA whole blood concentration in 30 cases of high risk uremia was monitored by the fluorescence polarization immunoassay(PIA).Results ①The CsA blood concentration of high risk uremia was much higher than that of the control at the early stage of post transplantation;②Incidence of acute rejection of high risk uremia was lower than that of the control;③The incidence of drug side effect to liver and pancreas was higher than taht of the control.Conclusion Monitoring whole blood concentration was helpful to prevent and relieve CsA side effect, and to keep effective immunosuppressive therapy.