| 亚硒酸钠细胞遗传毒及阈浓度 |
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| 引用本文： | 顾康生,苟振义,王德全,刘巧芳,韩燕.亚硒酸钠细胞遗传毒及阈浓度[J].西安交通大学学报(医学版),1992(4). |
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| 作者姓名： | 顾康生 苟振义 王德全 刘巧芳 韩燕 |
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| 作者单位： | 西安医科大学核医学研究室，西安医科大学核医学研究室，西安医科大学核医学研究室，西安医科大学核医学研究室，西安医科大学核医学研究室 西安 710061，西安 710061，西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 本文采用人外周血淋巴细胞培养,选用姐妹染色单体互换(SCE)和非程序DNA合成(UDS)两个指标进行了亚硒酸钠诱发细胞遗传毒试验。结果表明;较高浓度的亚硒酸钠均诱发了SCE和UDS阳性结果,提示其具有细胞遗传毒效应。此效应的阈浓度为6.48×10~(-7)mol/L。
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| 关 键 词： | 亚硒酸钠 淋巴细胞 阈浓度 细胞培养 |
THE CYTOGENOTOXICITY OF Na_2SeO_3 AND ITSTHRESHOLD CONCENTRATION |
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| Gu Kangsheng,Gou Zhenyi,Wang Dequan,et al.THE CYTOGENOTOXICITY OF Na_2SeO_3 AND ITSTHRESHOLD CONCENTRATION[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(4). |
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| Authors: | Gu Kangsheng Gou Zhenyi Wang Dequan |
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| Institution: | Department of Nuclear Medicine |
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| Abstract: | The cytogenotoxic effect of Na_2SeO_3 on lymphocytes in human whole blood culture was studied. This was done by means of analysis of sisterchromatid exchange (SCE) and determination of unscheduled DNA synthesis (UDS) with the use of scintillometric procedure and autoradiographic observation. The experiments showed that Na_2SeO_3induced a significant increase of SCE value and higher levels of UDS. These results indicate that Na_2SeO_3 has DNA-damaging potential and cytogenotocity, its threshold concentration was 6.48×10~(-7)mol/L. |
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| Keywords: | Sodium selenite lymphocyte threshold concentration cell culture |
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