| EFFECT OF SELENIUM ON IMMUNE FUNCTION OFERYTHROCYTE IN KASHIN-BECK DISEASE |
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| 作者姓名： | 戴晓霞 熊咏民 楚雍烈 王治伦 |
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| 作者单位： | Key Laboratory of Education Ministry for Environment and Genes associated with Diseases, Institute ofEndemic Disease, Medical School of Xi＇an Jiaotong University, Xi＇an 710061, China. |
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| 摘 要： | Objective To investigate the relationship between erythrocyte immune function and selenium （Se） level. Methods Forty-nine Kashin-Beck patients in endemic area aged 13- 1 6 years were divided into two groups and were orally given either selenized yeast or sodium selenite to provide 200 μg selenium per day for12 weeks. Erythrocyte selenium level, glutathione peroxidase activity, the rosette formation rates of red blood cells complement receptor typeⅠ （CR1）, the immune function of red blood cells, and circulating immune complexes（CIC） were determined. Results After supplementing with selenium for 12 weeks, erythrocyte selenium level, glutathione peroxidase activity, the rosette formation rates of red blood cells CR1 were significantly increased. But the difference in rosette formation rates of IC and CIC content was not significant between before and after Se supplementation. Gonclusion The increase of the immune function of the erythrocyte by selenium-supplement may be one of the effective mechanisms for the prevention of Kashin-Beck disease.
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| 关 键 词： | 硒元素 免疫功能 疾病治疗 地方病 |
| 文章编号： | 1671-8267（2006）01-0040-04 |
EFFECT OF SELENIUM ON IMMUNE FUNCTION OF ERYTHROCYTE IN KASHIN-BECK DISEASE |
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| Dai Xiaoxia,Xiong Yongmin,Chu Yonglie,Wang Zhilun.EFFECT OF SELENIUM ON IMMUNE FUNCTION OFERYTHROCYTE IN KASHIN-BECK DISEASE[J].Academic Journal of Xi’an Jiaotong University,2006,18(1):40-43,64. |
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| Authors: | Dai Xiaoxia Xiong Yongmin Chu Yonglie Wang Zhilun |
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| Abstract: | Objective To investigate the relationship between erythrocyte immune function and selenium (Se)level. Methods Forty-nine Kashin-Beck patients in endemic area aged 13- 16 years were divided into two groups and were orally given either selenized yeast or sodium selenite to provide 200 μg selenium per day for 12 weeks. Erythrocyte selenium level, glutathione peroxidase activity, the rosette formation rates of red blood cells complement receptor type Ⅰ(CR1), the immune function of red blood cells, and circulating immune complexes(CIC) were determined. Results After supplementing with selenium for 12 weeks, erythrocyte selenium level, glutathione peroxidase activity, the rosette formation rates of red blood cells CR1 were significantly increased. But the difference in rosette formation rates of IC and CIC content was not significant between before and after Se supplementation. Conclusion The increase of the immune function of the erythrocyte by selenium-supplement may be one of the effective mechanisms for the prevention of Kashin-Beck disease. |
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| Keywords: | Kashin-Beck disease selenium red blood cell immune function |
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