Using the implantable electrical stimulator for peripheral nerve rehabilitation: A study in an animal model |
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| Authors: | Bi-yu Rui Bing-fang Zeng Jin-wu Wang Shang-chun Guo Xin Chen |
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| Institution: | (1) Department of Neurosurgery, Taichung Veterans General Hospital, 407 Taichung, Taiwan, Republic of China;(2) Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, 407 Taichung, Taiwan, Republic of China;(3) Department of Neurology, Taichung Veterans General Hospital, 407 Taichung, Taiwan, Republic of China;(4) Department of Neurosurgery, Chang Bing Show Chwan Memorial Hospital, 505 Changhua, Taiwan, Republic of China;(5) Department of Veterinary Medicine, Institute of Medical Technology, National Chung-Hsing University, 402 Taichung, Taiwan, Republic of China;(6) Bioresource Collection and Research Center, Food Industry Research and Development Institute, 300 Hsinchu, Taiwan, Republic of China |
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| Abstract: | The present study presents a peripheral nerve injury animal model for evaluation of an implantable electrical stimulator we
designed. The evaluation was confirmed by ethological, electrophysiological and histologic study. Twenty New Zealand rabbits
were used. The left sciatic nerve was crushed with a micro-vessel clamp in all rabbits, and the stimulators were implanted
in ten rabbits. The other ten rabbits were in a control group. As compared with the implantation group, 3 and 6 weeks after
operation, the histology showed the typical pathologic atrophy by hematoxylin-eosin (HE), the motor nerve conduction velocity
(MCV) was found significantly slowed and the axon of crushed nerve at distal portion exhibited breakdown in the control group.
These results reveal that the implantable electrical stimulator was effective and was suitable for implantation in an animal
model. |
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| Keywords: | implantable stimulator animal model electrical stimulation peripheral nerve injury |
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