| 贫困山区孕期CMV感染与IL-6的关系 |
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| 引用本文： | 李芬,闫凤亭,韩蓁,王亚文,史小薇,李琦.贫困山区孕期CMV感染与IL-6的关系[J].西安交通大学学报(医学版),2002,23(2):196-197. |
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| 作者姓名： | 李芬 闫凤亭 韩蓁 王亚文 史小薇 李琦 |
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| 作者单位： | 1. 西安交通大学第一医院妇幼保健中心,西安,710061
2. 上海医科大学妇产科医院,上海,200011 |
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| 基金项目： | 卫生部自然科学基金赞助 (No .98 1 2 42 ) |
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| 摘 要： | 目的 研究贫困山区孕期巨细胞病毒 (Cytomegalovirus,CMV)感染状况 ,探讨孕期CMV感染与白细胞介素 6(Interleukin 6,IL 6)的关系。方法 用ELISA和PCR方法检测贫困山区30 5例正常孕妇外周血特异性CMVIgM抗体及CMVDNA ,对其中 48例孕期CMV感染者及68例孕期未感染CMV者进行随访 ,检测产后两周内乳汁及新生儿尿液CMVDNA ;并采用双抗体夹心ELISA法检测孕妇及乳母外周血中IL 6水平。结果 孕妇CMV活动性感染率 1 9.0 2 % ,孕期CMV活动性感染及乳汁排泄CMV者其外周血IL 6水平显著高于未感染者 (P <0 .0 5 )。结论 贫困山区孕期CMV感染率较国内外报道的高 ;IL 6在孕期活动性CMV感染中可能起着重要作用
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| 关 键 词： | 巨细胞病毒 妊娠 白细胞介素6 |
| 文章编号： | 0258-0659(2002)02-0196-02 |
| 修稿时间： | 2001年9月15日 |
The relationship between cytomegalovirus infection during pregnancy and IL-6 in mountainous area |
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| Abstract: | Objective To investigate the effects of interleukin 6 (IL 6) on cytomegalovirus (CMV) infection during pregnancy.Methods The specimens were taken from the blood of 305 pregnant women Among them, milk, blood and neonatal urine were taken from 48 women who were infected with CMV during pregnancy, within 2 weeks after delivery, maternal milk and blood were taken from 68 women who were not infected with CMV during pregnancy within 2 weeks after delivery of CMV IgM and DNA in blood, CMV DNA in milk and urine were detected to determine the concentration of IL 6 in the blood.Results The concentration of IL 6 in blood was significantly higher in CMV infection, CMV transmission to fetus or milk was higher than that did not transmit CMV ( P <0.05).Conclusion IL 6 is involved in CMV infection during pregnancy and CMV is transmitted from the mother to fetus and milk. |
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| Keywords: | cytomegalovirus pregnancy interleukin 6 |
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