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| 掺锶磷酸钙骨水泥的体外细胞生物学性能评价及其与掺锶量的相关性 | |
| 引用本文： | 岳进,郭大刚,孙翔,雷德林,毛天球.掺锶磷酸钙骨水泥的体外细胞生物学性能评价及其与掺锶量的相关性[J].西安交通大学学报(医学版),2008,29(5). |
| 作者姓名： | 岳进 郭大刚 孙翔 雷德林 毛天球 |
| 作者单位： | 1. 第四军医大学口腔医院颌面外科,陕西西安,710032;沈阳军区230医院,辽宁丹东,118000 2. 西安交通大学金属材料强度国家重点实验室,陕西西安,710049 3. 第四军医大学口腔医院颌面外科,陕西西安,710032 |
| 摘 要： | 目的 评价"SrHPO4/Ca4(PO4)2O/CaHPO4"系掺锶磷灰石骨水泥的生物相容性及其与掺锶量的关系.方法 通过急性全身毒性、热原性、溶血性、体外细胞毒性以及成骨细胞在材料表面的黏附、增殖与表达等实验,检测材料的性能及生物降解潜能.结果 "SrHPO4/Ca4(PO4)2O/CaHPO4"系掺锶磷灰石骨水泥的急性全身毒性、热原性、溶血性、体外细胞毒性均为合格.Sr-CPC的热原性、溶血性以及碱性磷酸酶值与掺锶量呈非线性关系.结论 含锶磷酸钙骨水泥体外细胞生物相容性良好,是安全的新型骨组织工程支架材料. |
| 关 键 词： | 掺锶磷灰石骨水泥 生物相容性 成骨细胞 成纤维细胞 |
Cytobiologic evaluation of Sr-containing calcium phosphate cement and correlation with the quantity of strontium |
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| Yue Jin,Guo Dagang,Sun Xiang,Lei Delin,Mao Tianqiu.Cytobiologic evaluation of Sr-containing calcium phosphate cement and correlation with the quantity of strontium[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2008,29(5). | |
| Authors: | Yue Jin Guo Dagang Sun Xiang Lei Delin Mao Tianqiu |
| Institution: | Yue Jin 1,2,Guo Dagang 3,Sun Xiang 1,Lei Delin 1,Mao Tianqiu 1 |
| Abstract: | Objective To investigate the biocompatibility of Sr-containing calcium phosphate cement series SrHPO 4/Ca 4(PO 4) 2O/CaHPO 4]. Methods A series tests,including acute systemic toxicity test,pyrogen test,hemolysis test,cytotoxicity test and in vitro biological behavior of osteoblasts,were designed to evaluate the cytobiology of the material. Results Sr-containing calcium phosphate cement had excellent biocompatibility and all of the biological evaluation tests were up to the standard.Pyrogen test,hemolysis test and ALP value of Sr-containing calcium phosphate cement behavior had non-linear relationships with the Sr-doped content.Conclusion Sr-containing calcium phosphate cement series are good in biocompatibility and can be widely used in tissue engineering research. |
| Keywords: | Sr-containing calcium phosphate cement biocompatibility osteoblast fibroblast |
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