慢性乙型病毒性肝炎血清铁及铁蛋白检测

目的探讨血清铁(SI)及铁蛋白(SF)在慢性乙型病毒性肝炎中的临床意义。方法用放射免疫测定法测定SF、原子吸收光谱法测定SI。结果慢性HBV感染者多出现SI和SF升高,而且随着病情的加重而升高,在重型肝炎组最为明显。SF、SI水平与HBV复制之间有一定的相关性,随病毒复制增高而增高,但无统计学意义。肝炎肝纤维化患者中,SF、SI随着Child-Pugh分级(A、B、C级)依次增高,SF与肝纤维化指标LN有相关性。SF升高的肝炎肝硬化患者并发症的发生率及复发率较高,临床预后较差。结论SF、SI在一定程度上反映了病毒性肝炎的病变严重程度及其预后,可以作为预测肝炎预后的一项参考指标。

Clinical meaning of serum ferritin, iron in chronic hepatitic B

Objective To investigate the clinical significance of serum ferritin level(SF),serum iron(SI) level in patients with chronic hepatitic B.Methods SF was measured by radioimmunoassay,serum iron was measured through atomic absorption spectrometry.Results Chronic HBV infectors mostly had high level of SF and SI,with severity of illness state increasing,especially in the group of severe hepatitis.The levels of SF and SI correlated with HBV duplication to a certain extent and specifically SF and SI increased with the increase of virus duplication.However,it had no statistical significance.Among the sufferers of hepatocirrhosis,numerical values of SF and SI turned to increase with the rank of Child-Pugh(A,B and C) and SF had the correlation with LN(the index of hepatic fibrosis).Patients of hepatocirrhosis with a high SF level had higher frequency of complications occurrence and reoccurrence,the clinical post-cure effects were worse.Conclusion SF and SI can be reference index in forecasting the degree of disease state,hepatic fibrosis and clinical post-cure.