莫索尼定对自发性高血压大鼠左室肥厚及c-myc基因表达的影响

目的　研究国产盐酸莫索尼定 (Mox)对自发性高血压大鼠 (SHR)左室肥厚的逆转作用及其可能机制。方法　2 0周龄的雄性自发性高血压大鼠 30只随机分为①Mox +SHR组 ,②Cap +SHR组 ,③SHR组 ,每组 10只。另设性别、周龄相配的SD大鼠 10只为正常对照组 (NC组 )。观察期末 ,测量左心室重 体重 (LVW BW )、左室胶原分数(CVF)、标准化血管周胶原面积 (PVCA)、肌间动脉中膜厚度 (AMT)及左室组织c myc基因表达的变化。 结果　Mox+SHR组不仅LVW BW明显低于SHR组 (3.4 6± 0 .13)mg·g- 1 vs(3.96± 0 .18)mg·g- 1 ,P <0 .0 1],CVF低于SHR组 (0 .0 86± 0 .0 18)vs(0 .0 4 6± 0 .0 15 ) ,P <0 .0 1],PVCA少于SHR组 (0 .6 9± 0 .11)vs(1.34± 0 .2 9) ,P <0 .0 1],AMT薄于SHR组 (7.97± 0 .73) μmvs(11.91± 1.16 ) μm ,P <0 .0 1],而且c myc表达量也低于SHR组 (0 .74±0 .16 )Avs(1.2 4± 0 .2 1)A ,P <0 .0 1]。结论　盐酸莫索尼定能够逆转自发性高血压大鼠的左室肥厚 ,对c myc基因表达的减少可能是其作用机制

Effects of moxonidine hydrochloride on left ventricular hypertrophy and c-myc gene expression in spontaneously hypertensive rats

Objective To investigate the regression effect of domestic moxonidine hydrochloride on left ventricular hypertrophy and the potential mechanism of spontaneously hypertensive rats (SHR). Methods Thirty male SHRs aged 20 weeks were randomly divided into Mox+SHR, Cap+SHR and SHR (10/group) groups. Ten age- and sex-matched sprauge-dawley rats were designed as normal control (NC). At the end of 13-week observation, the ratio of left ventricular weight/body weight (LVW/BW), collagen volume fraction (CVF), standardized perivascular collgen area (PVCA) and intramyocardial arterial average medial thickness (AMT) as well as c-myc gene expressiona (A) were assayed. Results LVW/BW, CVF, PVCA, AMT and c-myc gene expression in group Mox+SHR were significantly lower than those in group SHR LVW/BW (3.46±0.13)mg·g -1 vs (3.96±0.18)?mg·g -1, CVF(0.086±0.018) vs (0.046±0.015), PVCA (0.69±0.11) vs (1.34±0.29), AMT(7.97±0.73)?μm vs (11.9±11.16)?μm, A(0.74±0.16)A vs (1.24±0.21)A, P<0.01]. Conclusion Long-term antihypertensive treatment with moxonidine hydrochloride can reverse left ventricular hypertrophy in SHR.