大黄、地塞米松对应激性溃疡的影响

目的　研究大黄联用地塞米松对大鼠应激性溃疡的预防作用。方法　SD大鼠 80只 ,采用冷拘束制成应激性溃疡动物模型之后 ,随机分为 4组 :对照组、地塞米松干预组、大黄干预组、大黄联用地塞米松干预组 ,每组 2 0只 ,分别观察胃肠应激性溃疡的发生情况。结果　地塞米松干预组应激性溃疡发生率与正常组相同 ,大黄联用地塞米松组应激性溃疡发生率最低。结论　地塞米松并不增加应激性溃疡的发生率 ,而大黄联用地塞米松可降低应激性溃疡的发生率

The effects of rhubarb and dexamethasome on stress ulcer

Objective To study the preventive effects of rh ub arb and dexamethasone(DXM) on stress ulcer. Methods A total of 80 healthy SD rats were made into stress ulcer animal model with tend cold. They were randomly assigned into four groups, including normal control group(20) , DXM intervention group(20), rhubarb intervention group(20) and rhubarb & DXM i ntervention group(20).All of them were observed for the incidence of stress ulce r. Results The stress ulcer incidence were the same in DXM stress ulcer group and normal control group. The stress ulcer incidence in rhuba rb and DXM group was the lowest. Conclusion The DXM doesn't increase the incidence of stress ulcer, while the rhubarb with DXM does decreas e the incidence of stress ulcer.