| Fas、FasL在非小细胞肺癌中的表达及其与肿瘤免疫和细胞凋亡的关系 |
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| 引用本文： | 刘颖,吴金如,高元勋. Fas、FasL在非小细胞肺癌中的表达及其与肿瘤免疫和细胞凋亡的关系[J]. 西安交通大学学报(医学版), 2011, 32(1): 6-9 |
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| 作者姓名： | 刘颖 吴金如 高元勋 |
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| 作者单位： | 1. 郑州大学第二附属医院呼吸内科,河南郑州,450014
2. 襄樊市中心医院呼吸内科,湖北襄樊,445000 |
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| 摘 要： | 目的为探讨Fas/FasL系统在非小细胞肺癌(NSCLC)发生发展中所起的免疫逃逸作用,为临床早期诊断肺癌、判断预后、设计新的治疗策略提供依据。方法采用免疫组织化学方法检测Fas、FasL在NSCLC组织及正常肺组织中的表达,同时采用抗CD45RO抗体检测肿瘤组织中浸润淋巴细胞(TIL)的数量,应用TUNEL技术检测肺癌细胞凋亡。结果 Fas在肺癌组织低表达并存在异位表达,表达率与细胞分化有关;FasL在肺癌组织中高表达,表达率和细胞类型及淋巴结转移相关,与TIL浸润程度呈负相关,Fas表达与肺癌细胞凋亡水平无关。结论 NSCLC肺癌组织中普遍存在Fas表达的下调、异位表达及FasL高表达,导致癌细胞的免疫逃逸,参与NSCLC的发生和发展。
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| 关 键 词： | Fas/FasL 肿瘤组织中浸润淋巴细胞 免疫组化 CD45RO 非小细胞肺癌 细胞凋亡 TUNEL 免疫逃逸 |
Expression of Fas/FasL protein and its relationship with tumorigenesis immunology and apoptosis in non-small cell lung cancer |
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| LIU Ying,WU Jin-ru,GAO Yuan-xun. Expression of Fas/FasL protein and its relationship with tumorigenesis immunology and apoptosis in non-small cell lung cancer[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 2011, 32(1): 6-9 |
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| Authors: | LIU Ying WU Jin-ru GAO Yuan-xun |
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| Affiliation: | LIU Ying1,WU Jin-ru2,GAO Yuan-xun1(1.Department of Respiratory Diseases,the Second Affiliated Hospital ofZhengzhou University,Zhengzhou 450014,2.Department of Respiratory Diseases,Xiangfan City Central Hospital,Xiangfan 445000,China) |
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| Abstract: | Objective In order to provide evidence for early diagnosis,prognosis prediction and new treatment of lung cancer,we analyze the immune escape of the Fas/FasL system in the carcinogenesis and progress of non-small cell lung cancer(NSCLC).Methods Immunohisochemistry(IHC) method was used to determine the expression of Fas/FasL protein in NSCLC and normal lung tissues;CD45RO antibody and TUNEL technique were used to detect the tumor infiltrating lymphocytes(TILs) and apoptosis respectively.Results Fas expressio... |
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| Keywords: | Fas/FasL CD45RO TUNEL |
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