| C57小鼠生后小脑发育的体视学研究 |
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| 引用本文： | 张莉,田鹤,郭敏.C57小鼠生后小脑发育的体视学研究[J].西安交通大学学报(医学版),2011,32(3):279-281,289. |
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| 作者姓名： | 张莉 田鹤 郭敏 |
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| 作者单位： | 辽宁医学院组织学与胚胎学教研室,辽宁锦州,121001 |
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| 摘 要： | 目的观察C57小鼠生后小脑发育的形态学变化规律。方法应用HE染色、免疫组织化学技术结合体视学方法,对生后(P)7、14、21 d的C57小鼠小脑的形态学变化进行系统观察和定量分析。结果 P7 d,C57小鼠小脑的皮、髓质结构明显,皮质由外向内分4层:外颗粒层、分子层、浦肯野细胞层和内颗粒层。P7~21 d,除皮质的外颗粒层截面积逐渐减小最后消失之外,小脑的其他部分的截面积均逐渐增加;外颗粒层的体密度逐渐减小最后消失,小脑小叶和皮质的体密度先减小后增大,髓质先增大后减小,分子层逐渐增大;NeuN阳性细胞的面数密度和体密度逐渐降低,钙结合蛋白D-28K阳性细胞的面数密度逐渐降低,体密度逐渐增加。P21 d,皮质分3层:分子层、浦肯野细胞层和颗粒层。结论 C57小鼠生后小脑各部发育迅速,P7~21 d皮质由4层变为3层,外颗粒层逐渐变薄最后消失。
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| 关 键 词： | 小脑发育 小鼠 体视学 |
Stereological study on postnatal development of the C57 mouse cerebellum |
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| ZHANG Li,TIAN He,GUO Min.Stereological study on postnatal development of the C57 mouse cerebellum[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(3):279-281,289. |
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| Authors: | ZHANG Li TIAN He GUO Min |
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| Institution: | ZHANG Li,TIAN He,GUO Min (Department of Histology and Embryology,Liaoning Medical College,Jinzhou 121001,China) |
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| Abstract: | Objective To investigate the morphological changes in postnatal development of the C57 mouse cerebellum.Methods HE staining,immunohistochemical and stereological methods were used to analyze the development of the C57 mouse cerebellum at postnatal(P) 7,14 and 21 d.Results The structure of the cerebellar cortex and medulla was obvious on P 7 d,and the cortex was divided into 4 layers,that is,the external granular layer,molecular layer,Purkinje cell layer and internal granular layer.During P 7-21 d,the sectio... |
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| Keywords: | cerebellum development mouse stereology |
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