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| GDNF基因多态性与精神分裂症临床特征的相关性 | |
| 引用本文： | 马雪红,高成阁,王宝安,翟歆明,胡晓刚,李生斌,刘清波. GDNF基因多态性与精神分裂症临床特征的相关性[J]. 西安交通大学学报(医学版), 2011, 32(3): 307-310 |
| 作者姓名： | 马雪红 高成阁 王宝安 翟歆明 胡晓刚 李生斌 刘清波 |
| 作者单位： | 1. 西安交通大学医学院第一附属医院精神科,陕西西安,710061;宝鸡市康复医院,陕西宝鸡,721001 2. 西安交通大学医学院第一附属医院精神科,陕西西安,710061 3. 宝鸡市康复医院,陕西宝鸡,721001 4. 西安交通大学医学院法医系,陕西西安,710061 |
| 基金项目： | 陕西省科学技术研究发展计划项目 |
| 摘 要： | 目的探讨GDNF基因多态性与精神分裂症临床特征的相关性。方法对符合纳入标准的精神分裂症病例组及健康对照组进行临床资料收集及血样的采集,采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测GDNF基因多态性。选取GDNF基因2个SNP位点:rs2973050,rs2910702。所有数据应用SSPS13.0软件包处理。结果①哈迪温伯格平衡(Hardy-Weinberg s equilibrium)结果显示,GDNF基因rs2910702在病例组中偏离哈迪温伯格平衡(χ2=24.983,P=0.000);②GDNF等位基因频率在病例组与对照组中的分布无统计学差异(P>0.05),但基因型频率分布有统计学差异(P<0.05);③GDNF各基因型与精神分裂症的临床分型、PANSS量表各因子分无明显相关性。结论 rs2973050基因型C/C、rs2910702基因型G/G可能与精神分裂症的发生有关,为精神分裂症的危险基因型。 |
| 关 键 词： | 精神分裂症 胶质细胞源性神经营养因子 基因多态性 关联分析 GDNF基因 哈迪温伯格平衡 PANSS量表 |
Correlation between clinical characteristics of schizophrenia and gene polymorphisms of glial cell line-derived neurotrophic factor |
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| MA Xue-hong,GAO Cheng-ge,WANG Bao-an,ZHAI Xin-ming,HU Xiao-gang,LI Sheng-bin,LIU Qing-bo. Correlation between clinical characteristics of schizophrenia and gene polymorphisms of glial cell line-derived neurotrophic factor[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 2011, 32(3): 307-310 | |
| Authors: | MA Xue-hong GAO Cheng-ge WANG Bao-an ZHAI Xin-ming HU Xiao-gang LI Sheng-bin LIU Qing-bo |
| Affiliation: | MA Xue-hong1,2,GAO Cheng-ge1,WANG Bao-an2,ZHAI Xin-ming2,HU Xiao-gang2,LI Sheng-bin3,LIU Qing-bo3 (1.Department of Psychiatry,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,2.Baoji Kangfu Hospital,Baoji 721000,3.Department of Forensic Medicine,China) |
| Abstract: | Objective To explore the correlation between gene polymorphisms of glial cell line-derived neurotrophic factor(GDNF) and clinical characteristics of schizophrenia.Methods Altogether 303 schizophrenia patients and 300 healthy controls recruited were consistent with the inclusion and exclusion criteria.Their clinical data and blood samples were collected.The gene polymorphisms of GDNF were determined with PCR-RFLP technique.We selected 2 SNP loci of GDNF gene,rs2973050 and rs2910702.SPSS13.0 software was used... |
| Keywords: | schizophrenia glial cell line-derived neurotrophic factor(GDNF) gene polymorphism correlation analysis GDNF gene Hardy-Weinberg's equilibrium PANSS scale |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |