| 应用液体芯片-飞行时间质谱技术筛选血清中肺癌标志蛋白 |
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| 引用本文： | 杨拴盈,田应选,南岩东,卜丽娜,霍树芬,林秀丽,杜洁,尚文丽.应用液体芯片-飞行时间质谱技术筛选血清中肺癌标志蛋白[J].西安交通大学学报(医学版),2011,32(1):17-22. |
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| 作者姓名： | 杨拴盈 田应选 南岩东 卜丽娜 霍树芬 林秀丽 杜洁 尚文丽 |
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| 作者单位： | 西安交通大学医学院第二附属医院呼吸科,陕西西安,710004 |
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| 基金项目： | 国家自然科学基金资助项目，教育部新世纪优秀人才支持计划项目 |
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| 摘 要： | 目的 应用液体芯片-飞行时间质谱系统分析肺癌与对照组血清差异表达蛋白,筛选肺癌标志蛋白.方法 将105例肺癌患者和90例对照者44名正常人,46例良性肺疾病(BLDs)]的血清随机分成训练组(肺癌和对照各60例)和验证组肺癌45例(早期13例,晚期32例),对照30例(正常及BLDs各15例)].应用ClinPro...
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| 关 键 词： | 液体芯片质谱技术 肺癌 诊断 血清蛋白组学 ClinProt系统 |
Using liquid and MALDI-TOF-MS system to filter out protein markers of lung cancer |
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| YANG Shuan-ying,TIAN Ying-xuan,NAN Yan-dong,BU Li-na,HUO Shu-fen,LIN Xiu-li,DU Jie,SHANG Wen-li.Using liquid and MALDI-TOF-MS system to filter out protein markers of lung cancer[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(1):17-22. |
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| Authors: | YANG Shuan-ying TIAN Ying-xuan NAN Yan-dong BU Li-na HUO Shu-fen LIN Xiu-li DU Jie SHANG Wen-li |
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| Institution: | YANG Shuan-ying,TIAN Ying-xuan,NAN Yan-dong,BU Li-na,HUO Shu-fen,LIN Xiu-li,DU Jie,SHANG Wen-li(Department of Respiratory Medicine,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710004,China) |
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| Abstract: | Objective To use liquid and matrix assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS) system to analyze the differentially expressed proteins in the serum of lung cancer patients and control group so as to filter out protein markers of lung cancer.Methods We randomly divided the serum of the 105 lung cancer patients and 90 control patients(including 44 healthy people and 46 cases of BLDs) into training group(including 60 lung cancer cases and 60 control cases) and validation... |
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| Keywords: | liquid chip and MALDI-TOF-MS lung cancer diagnosis serum proteomics ClinProt system |
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