| 慢性乙肝肝硬化血小板减少与疾病相关性的研究 |
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| 引用本文： | 崔文娟,朱凤群,马列婷,赵英仁,蔺淑梅,樊万虎,叶峰.慢性乙肝肝硬化血小板减少与疾病相关性的研究[J].西安交通大学学报(医学版),2011,32(1):85-88. |
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| 作者姓名： | 崔文娟 朱凤群 马列婷 赵英仁 蔺淑梅 樊万虎 叶峰 |
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| 作者单位： | 西安交通大学医学院第一附属医院传染科,陕西西安,710061 |
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| 基金项目： | 陕西省科技计划基金资助项目 |
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| 摘 要： | 目的探讨慢性乙肝肝硬化血小板减少与血清血小板生成素(thrombopoietin,TPO)浓度及HBV-DNA载量之间的关系。方法测定26例血小板减少的慢性乙肝肝硬化肝功能代偿期患者、73例血小板减少的慢性乙肝肝硬化肝功能失代偿期患者、26例血小板正常的慢性乙肝肝硬化患者及25例健康对照的血小板参数;用酶联免疫吸附法(ELISA)测定血清TPO浓度;荧光定量PCR法测定99例血小板减少的慢性乙肝肝硬化患者的HBV-DNA水平。结果与健康对照组相比,血小板减少的慢性乙肝肝硬化肝功能代偿期组及慢性乙肝肝硬化肝功能失代偿期组的血小板显著降低(P<0.01),血小板减少的慢性乙肝肝硬化肝功能失代偿期组的血清TPO浓度显著升高(P<0.05),而血小板减少的慢性乙肝肝硬化肝功能代偿期组与血小板正常的慢性乙肝肝硬化组及健康对照组的血清TPO浓度相比均无统计学差异(P>0.05)。血小板减少的慢性乙肝肝硬化肝功能代偿期组、失代偿期组的血清TPO浓度与外周血小板计数之间均无相关性(P>0.05)。与HBV-DNA水平小于103IU/mL的血小板减少的慢性乙肝肝硬化患者组比较,HBV-DNA水平在103～106IU/mL及HBV-DNA水平大于106IU/mL的血小板均显著降低(P<0.05)。结论血小板减少可以作为评价慢性乙肝肝硬化的指标,但不能区别肝硬化肝功能处于代偿期还是失代偿期。慢性乙肝肝硬化血小板减少是多因素影响的,血清TPO水平在慢性乙肝肝硬化中增高,其对血小板减少的影响不大,而乙肝病毒载量高低对血小板减少的影响较大。
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| 关 键 词： | 乙型肝炎 肝硬化 血小板生成素 血小板参数 病毒 |
Correlation between thrombocytopenia in chronic hepatitis B and chronic hepatitis B with liver cirrhosis |
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| CUI Wen-juan,ZHU Feng-qun,MA Lie-ting,ZHAO Ying-ren,LIN Shu-mei,FAN Wan-hu,YE Feng.Correlation between thrombocytopenia in chronic hepatitis B and chronic hepatitis B with liver cirrhosis[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(1):85-88. |
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| Authors: | CUI Wen-juan ZHU Feng-qun MA Lie-ting ZHAO Ying-ren LIN Shu-mei FAN Wan-hu YE Feng |
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| Institution: | CUI Wen-juan,ZHU Feng-qun,MA Lie-ting,ZHAO Ying-ren,LIN Shu-mei,FAN Wan-hu,YE Feng(Department of Infectious Diseases,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China) |
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| Abstract: | Objective To investigate the relationship of thrombocytopenia with the serum concentration of thrombopoietin(TPO) and HBV-DNA load in chronic hepatitis B(CHB) patients with liver cirrhosis.Methods The values of platelets of 26 patients with CHB with liver cirrhosis,thrombocytopenia and compensated liver function,73 patients with the same disease but with decompensated liver function,26 CHB-liver cirrhosis patients with normal platelets,and 25 healthy controls were detected.The serum concentration of TPO was... |
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| Keywords: | hepatitis B liver cirrhosis thrombopoietin platelet parameter virus |
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