| PCNA与AgNOR在肺癌中的表达及意义 |
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| 引用本文： | 陈晓黎,黄莺,申富坤.PCNA与AgNOR在肺癌中的表达及意义[J].西安交通大学学报(医学版),1997(4). |
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| 作者姓名： | 陈晓黎 黄莺 申富坤 |
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| 作者单位： | 西安第二附属医院病理科!西安710004(陈晓黎，黄莺)，西安第二附属医院CT科(申富坤) |
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| 摘 要： | 应用肺癌增殖细胞核抗原（PCNA）免疫组化和核仁组成区（AgNOR）胶银染色法对比观察60例肺癌。结果表明，PCNA增殖指数（PI）与AgNOR计数均能较敏感的反应细胞增殖活性，且两者具有一定的线性相关性，其数量变化均与肺癌分型分级有关。结果还提示，PCNA与AgNOR均可作为肺癌分级诊断的参数，并可作为常规推广普及。
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| 关 键 词： | 肺肿瘤 免疫组织化学 核仁组成区 |
EXPRESSION AND SIGNIFICANCE OF THE PCNA AND AgNOR IN HUMAN LUNG CARCINOMA |
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| Chen Xiaoli,Huang Ying,Shen Fukun.EXPRESSION AND SIGNIFICANCE OF THE PCNA AND AgNOR IN HUMAN LUNG CARCINOMA[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1997(4). |
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| Authors: | Chen Xiaoli Huang Ying Shen Fukun |
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| Abstract: | The expression of PCNA and AgNOR counts in 60 cases of primary lung cancer was studied by using immunostaining of monoclonal antibody (PC-10) and silver-staining methods. The results showed that the proliferating index(PI) of PCNA positive ce1ls was linearly re1ated to AgNOR counts- Both can sensitively reflect cellular proliferating reactivity. These were also correlated with the histological type and differentiation of lung cancer.The results suggest that immunostaining of PCNA and AgNOR may be useful parameter in differential diagnosis of lung cancer. Therefore, our results indicate that immunostaining of PCNA and AgNORare valuable in popularizing application as routine. |
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| Keywords: | lung neoplasms immunohistochemistry nucleolar organizer region |
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