| 饮食诱发豚鼠胆结石及维生素C防止结石形成的实验研究 |
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| 引用本文： | 任斌,石景森,刘绍诰,孟清翠,吴瑾光,赵三斌.饮食诱发豚鼠胆结石及维生素C防止结石形成的实验研究[J].西安交通大学学报(医学版),1990(2). |
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| 作者姓名： | 任斌 石景森 刘绍诰 孟清翠 吴瑾光 赵三斌 |
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| 作者单位： | 西安医科大学第一附属医院外科学教研室，西安医科大学第一附属医院外科学教研室，西安医科大学第一附属医院外科学教研室，西安医科大学第一附属医院外科学教研室，西安医科大学第一附属医院外科学教研室，西安医科大学第一附属医院外科学教研室，北京大学化学系 |
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| 摘 要： | 本实验采用高胆固醇及低蛋白两种致石食物诱发豚鼠形成胆结石,8周后成石率均为100%;在致石食物中加入维生素C,成石率分别降至16.7%和52.9%并通过对动物胆石的细微结构观察和成份分析,肝脏、胆囊的亚微及超微结构的变化以及胆汁结合胆汁酸量及其组成的观测,探讨饮食成份改变诱发豚鼠胆结石及维生素C防止胆石形成的机制。
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| 关 键 词： | 胆结石 致石饮食 维生素C 预防 豚鼠 胆汁酸 |
STUDY ON GALLSTONE FORMATION INDUCED BY DIETS AND PREVENTED BY ASCORBIC ACID IN GUINEA PIGS |
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| Ren Bin,et al.STUDY ON GALLSTONE FORMATION INDUCED BY DIETS AND PREVENTED BY ASCORBIC ACID IN GUINEA PIGS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(2). |
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| Authors: | Ren Bin |
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| Abstract: | Two different diets(high cholesterol and low protein) were used to induce gallstone formation in guinea pigs. After the guinea pigs had been fed on lithogenie diets for 8 weeks, the rate of gallstone formation was 100% in both groups. However, when ascorbic acid was added in the diets, the rate of gallstone formation was reduced to 16.7% and 52,9% respectively. The mechanism of gallstone formation was explored through observing the effect of animals diet change on gallstone formation and the effect of ascorbic acid on gallstone prevention. At the same time, the micro-structure observation and the component analysis of gallstone, the change of ultrastructure of the liver and gallbladder, and the quantitative analysis of conjugated bile acids of biles were condueted. |
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| Keywords: | gallstone lithogenic diet ascorbic acids prevention guinea pig bile acid |
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