Comparison of osteogenesis between two kinds of stem cells from goat combined calcium phosphate cement in tissue engineering |
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| Authors: | Wei Zhao Jia-yu Lu Yong-ming Hao Xiu-li Zhang Xiao-hui Qu Li Hua Chunhua Cao De-rong Zou |
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| Institution: | (1) Department of Fixed Prosthesis and Implant Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece;(2) Department of Conservative Dentistry, Periodontology and Preventive Dentistry, School of Dentistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany;(3) Department of Pharmacology, School of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece; |
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| Abstract: | To explore the possible mechanism of osteogenesis for deciduous teeth stem cells (DTSCs) in vivo/ vitro, stem cells from goat
deciduous teeth (SGDs) were firstly isolated, induced and transplanted into immunocompromised mice. The SGDs’s mineralization
pattern and osteogenesis were compared with bone marrow messenchymal stem cells (BMMSCs) from goats. SGDs have similar osteogenic
differentiation pattern in vitro and bone-like tissue formation mechanism in vivo to BMMSCs; moreover SGDs have stronger alkaline
phosphatase (ALP) gene expression and osteopontin (OPN) gene expression levels than BMMSCs; also SGDs can form more bone-like
tissues than BMMSCs when cell-scaffold compounds are transplanted into immunocompromised mice. This pre-clinical study in
a large-animal model confirms that DTSCs may be an appropriate source of stem cells in repairing bone defects with tissue
engineering. |
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