内皮抑素的表达与直肠癌侵袭行为的关系

目的研究内皮抑素(ES)与直肠癌血管形成的关系,探讨其在直肠癌侵袭行为中的作用。方法应用免疫组化方法,检测10例正常直肠组织与40例直肠癌组织中ES蛋白的表达以及微血管密度(MVD)。结果ES在正常直肠组织中的表达明显高于直肠癌组织(P<0.05)。随直肠癌浸润深度的增加及淋巴结转移的发生,组织中ES蛋白的表达与MVD呈负相关关系(P<0.05)。结论ES表达降低,肿瘤血管生成增加,MVD升高,可促进直肠癌的局部浸润及淋巴结转移。

Relationship between endostatin expression and the invasion of rectal cancer

Objective To investigate the relation of endostatin(ES) and the vascular formation in rectal cancer,and the effect of ES on the invasion of rectal cancer.Methods The expression level of ES and microvessel density(MVD) in 10 cases of normal rectal tissues and 40 cases of rectal cancer were detected by immunohistochemistry staining.Results The expression level of ES in normal rectal tissues was obviously stronger than that in rectal cancer(P<0.05).There was a negative relation between the expression level of ES and MVD in rectal cancer with the changes of the depth of infiltration and lymph node metastasis(P<0.05).Conclusion With the decrease of ES,the number of knubbly vessels increases.The decrease of ES can promote infiltration of rectal cancer and metastasis of lymph node.