姜黄素对单纯性肥胖大鼠的减肥作用及其机制研究

目的探讨姜黄素对单纯性肥胖大鼠的减肥作用及其机制。方法给予单纯性肥胖大鼠姜黄素后,检测体重、脂体比、血脂和肝肾功能,并用组织病理及透射电镜观察脂肪组织结构的变化,探讨其可能的减肥机制。结果给予姜黄素后,可显著减缓单纯性肥胖大鼠体重增长速度,降低体脂含量(P<0.05);高剂量姜黄素可明显降低血清中TC水平(P<0.05),显著提高HDL、apoA水平(P<0.05);超微结构观察显示,给予姜黄素后,脂肪细胞的体积明显减小,核膜、细胞间质等脂肪含量明显减少。结论姜黄素具有降脂减肥作用。其机制可能是通过提高apoA含量,促进HDL-C合成;降低apoB水平,加速LDL-C分解,从而加速血清总胆固醇、三酰甘油分解、转化。

The study of weight control and the mechanism on the model of simplicity obesity rats by curcumin

Objective To evaluate the weight control and mechanism of curcumin on simplicity obesity rats.Methods To assess the weight control function,different dose of curcumin were given to the model of simplicity obesity rats.The blood lipids,liver and nephridium function were measured.Pathological and transmission electron microscrope were used to observe the changes of lipocyte.Results Different dose of curcumin on the model of simplicity obesity rats could cause a significant diminished weight and content of lipocyte,decrease level of serum TC,increase level of serum HDL,apoA.A significant diminished volume and content of lipocyte of karyotheca and cytoplasm in the ultrastructure of lipocyte were also found.Conclusion The curcumin has the weight control function through improving the level of serum apoA,promoting HDL-C synthesis,decreasing the level of serum apoB,accelerating LDL-C decomposition,and then accelerating the level of serum TC and TG decomposition.