| ANTITUMOR MECHANISM OF GEM10 BY THE NATURAL KILLER ACTIVITY AND INTERLEUKIN-2 PRODUCTION |
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| 作者姓名： | 陈静宏 张健 杨占田 陈高平 苏敏 |
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| 作者单位： | Institute of Endemic Diseases，Medical School of Xi'an Jiaotong University，Xi 'an 710061，China，Department of Pathology，Medical School of XianJiaotong University，Xian710061，China，Institute of Endemic Diseases，Medical School of Xi'an Jiaotong University，Xi 'an 710061，China，Department of Pathology，Medical School of XianJiaotong University，Xian710061，China，Department of Pathology，Medical School of XianJiaotong University，Xian710061，China |
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| 基金项目： | ThisresearchwassupportedbytheNationalNaturalScienceFoundationofChina(No.29170226) |
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| 摘 要： | Studiesongermaniumcompoundsshowedthattheyhavemanybiologicaleffects ,suchasanti tu mor1] ,improvingimmunity2 ] ,reducingthecon centrationofbloodcholestrolandtrilycerides3] ,in hibitingvirusreproduction ,butthesideeffectsoftoxicrestricttheirclinicaluses4 ,5] .Therefore ,itisstillnecessarytodevelopothernewcompoundsoforganogermaniums.GeM 10 ,aneworganicgerma niumcompounds alkili metalcomplexcombinedwitheffectiveextractsofsomeChinesetraditionalherbs ,hasbeendemonstratedtobesaferandmorereliable.…
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| 关 键 词： | IL-2 NK GEM MTT OS |
ANTITUMOR MECHANISM OF GEM10 BY THE NATURAL KILLER ACTIVITY AND INTERLEUKIN-2 PRODUCTION |
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| Chen Jinghong,Zhang Jian,Yang Zhantian,Chen Gaoping,Su Min Institute of Endemic Diseases,Medical School of Xi'an Jiaotong University,Xi 'an ,China.ANTITUMOR MECHANISM OF GEM10 BY THE NATURAL KILLER ACTIVITY AND INTERLEUKIN-2 PRODUCTION[J].Academic Journal of Xi’an Jiaotong University,2004,16(2):144-147. |
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| Authors: | Chen Jinghong Zhang Jian Yang Zhantian Chen Gaoping Su Min Institute of Endemic Diseases Medical School of Xi'an Jiaotong University Xi 'an China |
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| Institution: | 1. Institute of Endemic Diseases, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
2. Department of Pathology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China. |
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| Abstract: | Objective To investigate the anti-tumor effects of GeM10 by the natural killer(NK) cells activities and the production of Interleukin-2 (IL-2) in peripheral blood mononuclear cells (PBMNCs). Methods Assay of human NK cells activities by dye rejection assay in vitro and production of IL-2 in PBMNC by IL-2 bioassay with IL-2 dependent cell line CTLL2 and MTT colorometric method. Results GeM10 could significantly stimulate NK activities (60μg*mL -1 GeM10: 17.077±7.665, 120μg*mL-1 GeM10: 24.9±13.04; control: 7.72±4.64, P<0.05). GeM10 could up-regulate the production of IL-2 of PBMNCs in tumor patients(60μg*mL-1 GeM10: 2.965±1.183; 120μg*mL-1 GeM10: 2.28±0.847; control: 1.792±0.823, P<0.05).Conclusion The GeM10 not only can stimulate the NK activities but also increase the IL-2 production by PBMNCs in tumor patients. These findings indicate that the GeM10 may have promise as an anti-tumor drug and a biological response modifier in clinic. |
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| Keywords: | GeM10 inhibiting tumor growth natural killer ac tivity Interleukin-2 production |
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