| 硒对阿霉素心脏中毒的防护作用 |
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| 引用本文： | 吴霭如,季米托夫.硒对阿霉素心脏中毒的防护作用[J].西安交通大学学报(医学版),1987(2). |
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| 作者姓名： | 吴霭如 季米托夫 |
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| 作者单位： | 第一附属医院妇产科学教研室，美国密执安州大学医学系 教授 |
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| 摘 要： | 静脉注射阿霉素使大白鼠产生心脏中毒,并在注射阿霉素前用硒处理。然后测定大白鼠血浆及心脏匀浆组织中过氧化氢的释放和化学发光。观察硒对阿霉素引起心脏中毒的影响。实验结果:阿霉素组过氧化氢的释放(6.553±0.474nmole)与对照组(10.437±0.758nmole)相比明显降低(P<0.001)。而硒加阿霉素组(8.637±0.987nmole)与对照组相比也较为减少。但阿霉素组过氧化氢值与硒加阿霉素组之间有着明显差异(P<0.001)。单独使用硒时不影响过氧化氢的释放(9.505±1.500nmole)。阿霉素组化学发光(1061.57±159.24CPM)与对照组(4458.60±976.64CPM)相比较低(P<0.001),硒加阿霉素组(1464.97±79.62CPM)与对照组相比也较低(P<0.001),而且阿霉素组与硒加阿霉素组之间存在着一定差异P<0.001),硒组值(3715.50±981.95CPM)与对照组相比化学发光影响不大。结果提示:阿霉素可阻止心肌氧代谢产物的释放。而在使用阿霉素前用硒处理可部分矫正阿霉素引起的心脏中毒。
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THE PROTECTIVE EFFECT OF SELENIUM AGAINST ADRIAMCIM CARDIAC TOXICITY |
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| Wu Airu.THE PROTECTIVE EFFECT OF SELENIUM AGAINST ADRIAMCIM CARDIAC TOXICITY[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1987(2). |
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| Authors: | Wu Airu |
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| Abstract: | The effect of selenium (Se) was studied in an established model of Adria- mycin(ADR)cardiac toxicity.Chenilum- inescance and hydrogen peroxide (H_2O_2) release were determined in heart homogen- ares from rats injected with ADT;both were decreased in homogenates from treated animals compared to controls.This sup- pressive effect of ADR was corrected if the animals were pretreated with selenium. Experiments with bovine superoxide dismu- tase (SOD) showed inhibition of SOD activity by ADR;this might explain decreased H_2O_2 production in presence of ADR.Results from this study suggest that ADR blocks the release of oxygen produ- cts by heart muscle under certain condi- tions. |
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| Keywords: | doxorubicin toxicity selenium pharm myocardium Pathol |
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