儿童桥本氏病的临床和实验室特征

以成人桥本氏病60例为对照，分析了60例儿童桥本氏病。显示：①阳性的自身免疫甲状腺病家族史较成人组多见（P＝0.0126）；②甲状腺峡部大为主者多于成人组（X2=49，P＜0.05）；甲状腺质地硬或韧如橡皮者显著少于成人组（X2=12．48，P＜0．001），伴结节者显著少于成人组（X2=8．2，P＜0.01）；③甲状腺球蛋白抗体（TGAb）和微粒体抗体（TMAb）阴性者显著多于成人组（X2=5．1和X3=5．81，P均＜0．05）；④淋巴细胞型显著多于成人组（X2=7.01，P＜0．01），而嗜酸细胞型明显少于成人组（X3=3．89，P＜0．05）；⑤甲状腺肿大程度、生化和碘代谢，两组相比差异无显著性（P＞0．05）。

THE CLINICAL AND LABORATORY CHARACTERSOF CHILD HOSHIMOTO'S DISEASE

in order to study the clinical and laboratorycharacters of the child Hoshimoto's disease,we investigated60 child cases. Comparing with the adult Hoshimoto's disease cases (n = 60) which are chosen randomly and diagnosied by thyroid cytological and/or histological evidence,child Hoshimoto's disease (n = 60,age<14 years) had thefollowing characters= (1 ) More cases with positive familyhistory could be found in child group than in adult group(P = 0. 0126) ; (2) Enlargement of thyroid isthamus appeared more frequently in child group than in adult group(ac = 4. 9, P < 0. 05 ), but the number of patients havingfirm of tough-rubber-like thyroid gland in adult group issignificant more than that in child (X2= 12. 48, P <0. 001)and in the adult group more patients could be found thyroidnodules (σ2 = 8. 2, P <0. 01 ) ; (3)The number of patientswith negative TGAb and TMAb in child group was significant more than that in adult group (X2= 5. 1, P <0. 05 andac = 5. 81, P < 0. 05 ) ; (4)The cytology and/or histologystudy showed that pathological type of lymphocyte in childpatients was more than that in adult group (X2=7. 01, p <0. 05), while the type of eosinophil was less than that of theadult group (X2= 3. 83, P <0. 05) ; (5)No significant difference of biochemistry, metabolism of iodine and the size ofthyroid gotter,could be found between the child group andthe adult group (P >0. 05).