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| 人脑胶质瘤nm23-H1蛋白及PCNA的表达 | |
| 引用本文： | 张仲林,刘楚伟,张晓东,鲍刚,韩水平.人脑胶质瘤nm23-H1蛋白及PCNA的表达[J].西安交通大学学报(医学版),2004,25(6):578-580. |
| 作者姓名： | 张仲林 刘楚伟 张晓东 鲍刚 韩水平 |
| 作者单位： | 1. 西安交通大学第一医院神经外科,陕西西安,710061 2. 西安长安医院,陕西西安,710021 3. 西安交通大学医学院病理学教研室,陕西西安,710061 |
| 摘 要： | 目的 研究人脑胶质瘤中nm2 3 H1蛋白和增殖细胞核抗原 (PCNA)表达状况。方法 采用免疫组化染色技术 ,对 5 3例人脑胶质瘤石蜡切片中nm2 3 H1蛋白和PCNA进行检测。结果 5 3例人脑胶质瘤免疫组化染色结果显示 ,人脑胶质瘤I级、II级中nm2 3 H1阳性细胞显著高于Ⅲ、Ⅳ级 (P <0 .0 5 ) ;Ⅲ、Ⅳ级中PCNA阳性细胞显著高于I、II级(P <0 .0 5 ) ,但PCNA蛋白表达与nm2 3 H1表达无显著相关性。结论 nm2 3 H1蛋白低表达及PCNA高表达与脑胶质瘤的病理学分级相关 ;nm2 3 H1表达可能成为脑胶质瘤的浸润与转移的指标。 |
| 关 键 词： | 胶质瘤 nm23H1 PCNA 免疫组织化学 |
| 文章编号： | 1671-8259(2004)06-0578-03 |
| 修稿时间： | 2004年2月5日 |
Expression of nm23-H1 and PCNA in human glioma cells |
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| Zhang Zhonglin,Liu Chuwei,Zhang Xiaodong,Bao Gang,Han Shuiping.Expression of nm23-H1 and PCNA in human glioma cells[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2004,25(6):578-580. | |
| Authors: | Zhang Zhonglin Liu Chuwei Zhang Xiaodong Bao Gang Han Shuiping |
| Abstract: | Objective To investigate the ex pr ession of nm23-H1 protein and proliferating cell nuclear antigen (PCNA) in huma n glioma cells. Methods Expression of nm23-H1 and PCNA in 53 br ain gliomas were detected by immunohistochemistry. Results The immunohistochemistry staini ng of nm23-H1 protein in low-grade astrocytomas (grades Ⅰ and Ⅱ) was significantly higher than that in high-grade astrocytomas (grades Ⅲ and Ⅳ). The immunohistochemistry staining of PCNA in high-grade astrocytomas was s ignificantly higher than that in low-grade astrocytomas. Conclusion The lower expression of nm23-H1 protein and the higher expression of PCNA are correlated with the pathological grade of glioma cells. The expression of nm23-H1 may be used as a hopeful marker for predicting the metastastic potential of gliomas. |
| Keywords: | gliomas nm23-H1 proliferating cell nuclear ant igen (PCNA) immunohistochemistry |
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