| 高压静电场对丝裂霉素C抗癌作用的协同效应 |
| |
| 引用本文： | 严羚玮,伊卫国.高压静电场对丝裂霉素C抗癌作用的协同效应[J].大连铁道学院学报,2010(2):82-84. |
| |
| 作者姓名： | 严羚玮 伊卫国 |
| |
| 作者单位： | 大连交通大学理学院;大连交通大学软件学院; |
| |
| 摘 要： | 以体外培养的人肝癌细胞SMMC7721和小鼠Lewis肺癌细胞为靶细胞,采用MTT比色法分别检测HVEF和MMC单独使用及联合应用对癌细胞增殖的抑制效果,并根据抑制率判定协同效应,从而探讨高压静电场（HVEF）与丝裂霉素C（MMC）联合应用对癌细胞生长是否具有协同抑制作用.结果表明：经HVEF与MMC联合作用后,两种癌细胞的增殖活性均低于单独使用MMC组,人肝癌细胞SMMC7721下降了20%~38%（P〈0.01）,小鼠Lewis肺癌细胞下降了7%~15%（P〈0.01）,且两种方法具有协同效应,说明一定强度的高压静电场能够增强丝裂霉素C的抗癌作用.
|
| 关 键 词： | 高压静电场 肿瘤 药物协同效应 |
Synergic Effect of High-Voltage Electrostatic Fields and Mitomycin C on Anti-Cancer Action |
| |
| YAN Ling-wei,YI Wei-guo.Synergic Effect of High-Voltage Electrostatic Fields and Mitomycin C on Anti-Cancer Action[J].Journal of Dalian Railway Institute,2010(2):82-84. |
| |
| Authors: | YAN Ling-wei YI Wei-guo |
| |
| Institution: | YAN Ling-wei1,YI Wei-guo2(1.School of Mathematics , Physics,Dalian Jiaotong University,Dalian 116028,China,2.Software Institute,Dalian 116052,China) |
| |
| Abstract: | To observe the synergic effect of high-voltage electrostatic field(HVEF) and mitomycin C(MMC) on anti-cancer action,human liver cancer cells and mouse Lewis lung cancer cells were used in vitro.The MTT assay was adopted to detect the inhibition of the cell proliferation after processed in HVEF and MMC.The synergic anti-cancer effects were evaluated according to the inhibitory rates.Both kinds of cancer cell proliferation activities of the HVEF+MMC groups are lower than the MMC groups.Compared with the contr... |
| |
| Keywords: | high-voltage electrostatic field neoplasms drug synergism |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
