幽门螺杆菌感染与胃黏膜环氧化酶-2表达的关系

目的　探讨幽门螺杆菌 (H .pylori)感染与胃黏膜环氧化酶 2 (COX 2 )表达的关系。 方法　用免疫组化方法检测 2 0例H .pylori阳性、14例H .pylori阴性的慢性胃炎胃窦黏膜COX 2表达 ,比较根除H .pylori前后胃窦黏膜COX 2表达的变化。结果　H .pylori阳性患者COX 2平均阳性细胞率 (3 5.8± 5.5) % ]显著高于H .pylori阴性者(P <0 .0 1) ;成功根除H .pylori的 15例患者 ,治疗前胃黏膜COX 2平均阳性细胞率明显高于治疗后 (P <0 .0 0 1)。结论　H .pylori感染诱导胃黏膜COX 2表达

Association between Helicobacter pylori infection and expression of cyclooxygenase-2 in gastric mucosa

Objective To investigate the effect of H.pylori infection on cyclooxygenase-2(COX-2)expression in gastric antral mucosa. Methods The expression of COX-2 in 20 patients with H.py lori -infected chronic gastritis and in 14 with uninfected chronic gastritis w ere investigated by immunohistochemical method. The expressions of COX-2 in the antral mucosa were compared before and after H.pylori eradication. Results The mean percentage of the cells stained with COX-2 was s ignificantly higher in H.pylori -infected mucosa than that in uninfected mucosa ( P < 0.01 ). The mean percentage of the cells stained with COX-2 was significantly higher in H.pylori -infected mucosa than mucosa in which H.pylori had been successfully eradicated( P < 0.001 ). Conclusion H.pylori infection may lead to overexpression of COX-2 in gastric antral mucosa.