| 睾酮对心肌梗塞大鼠心肌线粒体Ca~(2+)—ATP酶活性的影响 |
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| 引用本文： | 宋世文,张万年,刘铸.睾酮对心肌梗塞大鼠心肌线粒体Ca~(2+)—ATP酶活性的影响[J].西安交通大学学报(医学版),1992(3). |
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| 作者姓名： | 宋世文 张万年 刘铸 |
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| 作者单位： | 西安医科大学病理生理学教研室，西安医科大学病理生理学教研室，西安医科大学病理生理学教研室 西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 本文采用实验性心肌梗塞(MI)大鼠模型。动态观察了肌注睾酮对非梗塞区心肌线粒体Ca~(2+)—ATP酶活性的影响。结果显示,MI后1d,非梗塞区心肌线粒体Ca~(2+)—ATP酶活性显著高于正常对照组(P<0.05),之后,随梗塞时间的延长,Ca~(2+)—ATP酶活性逐渐降低;肌注睾酮可明显增加MI大鼠心肌线粒体Ca~(2+)—ATP酶的活性(P<0.05),防止或延缓MI后非梗塞区心肌线粒体Ca~(2+)—ATP酶活性的过度降低。
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| 关 键 词： | 心肌梗塞 睾酮 线粒体 Ca~(2+)—ATP酶 |
THE EFFECTS OF TESTOSTERONE ON MITOCHONDRIA Ca~(2+)-ATPase ACTIVITY IN NON-ISCHEMIC AREA FOLLOWING MYOCARDIAL INFARCTION IN RAT |
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| Song Shiwen,Zhang Wannian,Liu Zhu.THE EFFECTS OF TESTOSTERONE ON MITOCHONDRIA Ca~(2+)-ATPase ACTIVITY IN NON-ISCHEMIC AREA FOLLOWING MYOCARDIAL INFARCTION IN RAT[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(3). |
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| Authors: | Song Shiwen Zhang Wannian Liu Zhu |
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| Institution: | Cardiovascular Pathophysiology Research Laboratbry |
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| Abstract: | The effects of testosterone on the mitochondria Ca~(2+)—ATPase activity of uninfarcted ventricular septum following myocardial infarction (MI) was observed dynamically by using the experimental MI model in rat. The results showed that on l day after MI the mitochondria Ca~(2+)—ATPase activity of non—ischemic area was more higher than that of the normal control group (p<0.05),but with the MI time on,the mitochondria Ca~(2-)—ATP ase activity gradually reduced. The testosterone treatment was able to increase the mitochondria Ca~(2+)—ATPase activity(p<0.05),and prevent or retard the unduly decrease of Ca~(2-)—ATPase activity of non—ischemic area after MI. |
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| Keywords: | myocardial infarction testosterone mitochondria Ca~(2+) —ATPase |
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