| 吡格列酮对胰岛素抵抗型多囊卵巢综合征患者脂肪细胞因子的影响 |
| |
| 引用本文： | 宋青,苟文丽.吡格列酮对胰岛素抵抗型多囊卵巢综合征患者脂肪细胞因子的影响[J].西安交通大学学报(医学版),2010,31(2). |
| |
| 作者姓名： | 宋青 苟文丽 |
| |
| 作者单位： | 西安交通大学医学院第一附属医院妇产科,陕西西安,710061 |
| |
| 基金项目： | 陕西省科技攻关项目(No.2008K15-02)Supported by the Sci-tech Research Project of Shaanxi Province |
| |
| 摘 要： | 目的 探讨胰岛素增敏剂吡格列酮在治疗胰岛素抵抗型多囊卵巢综合征(PCOS)时脂肪细胞因子瘦素、抵抗素及脂联素的变化.方法 35例胰岛素抵抗型PCOS患者用吡格列酮治疗12周,监测治疗前、后患者的临床指标,检测治疗前、后患者血清脂肪因子、空腹血糖、胰岛素、性激素水平和血脂情况.结果 35例患者中88.5%月经和排卵功能改善,腰臀比和F-G评分与治疗前比较显著下降(P<0.05),体重指数也有下降,但差异无统计学意义(P>0.05);治疗后黄体生成素(LH)和睾酮(T)水平显著下降(P<0.01),卵泡刺激素(FSH)水平无显著变化(P>0.05);空腹血清胰岛素和胰岛素抵抗指数(HOMA-IR)较治疗前显著下降(P<0.01),空腹血糖在治疗后略有下降,但差异无统计学意义(P>0.05);治疗后总胆固醇、甘油三脂和低密度脂蛋白较前显著下降(P<0.01,P<0.05),高密度脂蛋白较前显著升高(P<0.01);瘦素和抵抗素较治疗前显著下降(P<0.05),脂联素较前显著升高(P<0.05).结论 胰岛素增敏剂吡格列酮可有效改善胰岛素抵抗型PCOS患者的临床体征、胰岛素敏感性和糖、脂代谢状况;脂肪细胞因子瘦素、抵抗素和脂联素可能参与PCOS的胰岛素抵抗(IR)的发生、发展,且吡格列酮可能通过改善血清脂肪细胞因子而发挥其治疗PCOS、改善IR的疗效.
|
| 关 键 词： | 吡格列酮 多囊卵巢综合征 胰岛素抵抗 瘦素 抵抗素 脂联素 |
Effects of pioglitazone on serum adipocytokines in polycystic ovary syndrome patients with insulin resistance |
| |
| SONG Qing,GOU Wen-li.Effects of pioglitazone on serum adipocytokines in polycystic ovary syndrome patients with insulin resistance[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2010,31(2). |
| |
| Authors: | SONG Qing GOU Wen-li |
| |
| Institution: | SONG Qing,GOU Wen-li(Department of Obstetrics & Gynecology,the First Affiliated Hospital,Medical School of Xi\'an Jiaotong University,Xi\'an 710061,China) |
| |
| Abstract: | Objective To investigate the effects of pioglitazone on serum adipocytokines(leptin,resistin and adiponectin) in polycystic ovary syndrome(PCOS) patients with insulin resistance(IR).Methods Thirty-five PCOS patients with IR were treated with pioglitazone 15mg/d for 12 weeks.The results of ovulation induction were observed.The changes of fasting plasma glucose(FPG),fasting serum insulin(FINS),serum levels of leptin,resistin and adiponectin,follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosteron... |
| |
| Keywords: | pioglitazone polycystic ovarian syndrome insulin resistance leptin resistin adiponectin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
