CLINICAL AND EXPERIMENTAL STUDY OF DL-TETRAHYDROPALMATINE EFFECT IN THE TREATMENT OF SUPRAVENTRICULAR ARRHYTHMIA

DI-THPisanalkaloidisolatedfromcorydalisturtschaninoviiYanhusuo.AlthoughalargenumberofreportsthatsupportedtheoryofCa2 channelblockersincediscoveringofitsexperimentalanti-arrhythmicaction'in1985,clinicallyanti-arrhythmicapplicationhasnotbeenreportedbynow.ThereforeweobserveditsefficacyandsafetyintreatmentofSVPB,andstudieditselectrophysiologicmechanisminrabbits.MATERIALSANDMETHODS1ClinicalDataandMethod'1.1ObjectThestudyinvolvesthepatientswithsinusrhythmsSVPBswhoneededtreatmentandhad…

CLINICAL AND EXPERIMENTAL STUDY OF DL-TETRAHYDROPALMATINE EFFECT IN THE TREATMENT OF SUPRAVENTRICULAR ARRHYTHMIA

Short-term efficacy and safety or dl-tetrahydropeimtine (dl-THP) effect in treatmentof supraventricularoremature beats (SVPS ) were studied with doubl-blind control. A 24h ambulato ry elettrocardiogram (Holier) was Performed to hudge the therapeutic efficacy before and after themedicatiou in all the 33 petients who took 300 mg/d, 450 mg/d, 600 mg/d dl-THP tblet in turn perweek. Total effective rate is 66. 7% ; more than 90% SVPBS disappear .in 18. 2% ; and more than75% SVPB. disappear in 48. 5%. Otherwise total affective rate is 13. 3% in placebo group. There issignificant differnce between the two groups (P < 0. 01). The important adverse reactions areletharey (24' 2% ), occasional nausea and vomiting. We demonstrate that dl-THP can prolong A-Hinterval by determining His bundle,electrogram (HBE) in rabbits, so P-R interval lengthed can befound in surface ECG. Exploitation of dl-THP veinous preartion may be one of the,rfertove drugto treat paroxysmal supraventricular tacbycardia(PSVT).