C反应蛋白与高血压病、冠心病关系的临床研究

目的分析高血压病、冠心病患者血清C反应蛋白(CRP)的变化及其与相关临床指标的关系。方法测定143例高血压病、108例冠心病患者和120例健康体检者的血清CRP、空腹血糖(FBG)、血脂及体积指数(BMI)并做相关分析。结果高血压和冠心病组CRP水平显著高于正常对照组(P<0.01);高血压1级与3级间CRP差异有显著性(P<0.05);急性心肌梗死(AMI)组与不稳定型心绞痛(UAP)组CRP高于稳定型心绞痛(SAP)组,差异有显著性(P<0.05);CRP与年龄、TG、FBG呈显著正相关,与HDL-C呈显著负相关(P<0.05)。结论①CRP是炎症标志物,高血压与冠心病患者血清CRP显著升高,提示患者体内存在炎症反应;②CRP水平反映了高血压和冠心病患者的病变程度。

The clinical investigation of C-reactive protein in patients with essential hypertension and patients with coronary heart disease

Objective To observe the changes of serum C-reactive protein(CRP) in patients with essential hypertension(HBP) and patients with coronary heart disease(CHD),and to analyse the relationship between C-reactive protein and some correlative clinical markers.Methods CRP was measured in 143 patients with essential hypertension,108 patients with coronary heart disease and 60 normal persons;at the same time,fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) and body mass index(BMI) were measured.Results Serum levels of CRP were significantly higher in patients with hypertension and with coronary heart disease than those of controls (P<0.01);the difference between hypertension grade 1 and grade 2 was significant(P<0.05);serum levels of CRP in AMI group and UAP group were significantly higher than those in SAP group(P<0.05);CRP has positive correlation with age,TG and FBG,and negative correlation with HDL-C(P<0.05).Conclusion CRP is an inflammation marker,and serum levels of CRP in patients with hypertension and in patients with coronary heart disease increase significantly,which suggests inflammation reaction in HBP patients and CHD patients the levels of CRP react to the degree of disease correspondingly in HBP patients and CHD patients.