| 西洋参茎叶皂甙对家兔窦房结电活动和豚鼠心肌收缩性的影响 |
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| 引用本文： | 马欣,赵松珍,王尚农.西洋参茎叶皂甙对家兔窦房结电活动和豚鼠心肌收缩性的影响[J].西安交通大学学报(医学版),1998(1). |
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| 作者姓名： | 马欣 赵松珍 王尚农 |
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| 作者单位： | 西安药理学教研室!西安，710061，西安第一临床医学院神经内科，北京市建筑职工医院心脏内科 |
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| 摘 要： | 西洋参茎叶皂甙（PanaxQuinquefoliumSaponin．PQS）200mg·L-1和800mg·L－1减慢离体家兔窦房结优势起搏细胞4相自动去极化速率，动作电位0相自动除极速率，降低窦房结动作电位幅度。PQS200mg·L－1抑制离体豚鼠心房肌静息后增强现象。结果提示，PQS具有阻断心肌细胞Ca2+内流作用。
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| 关 键 词： | 西洋参茎叶皂甙 家兔 窦房结 豚鼠 心房肌 |
EFFECTS OF PANAX QUINQUEFOLIUM SAPONIN ON RABBIT SINOATRIAL NODE ELECTRICAL ACTIVITY AND MYOCARDIAL CONTRACTION IN GUINEA PIGS |
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| Ma Xin, Zhao Songzhen, Wang Shangnong.EFFECTS OF PANAX QUINQUEFOLIUM SAPONIN ON RABBIT SINOATRIAL NODE ELECTRICAL ACTIVITY AND MYOCARDIAL CONTRACTION IN GUINEA PIGS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1998(1). |
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| Authors: | Ma Xin Zhao Songzhen Wang Shangnong |
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| Abstract: | Panax quinquefolium saponin (PQS) 200mg· L-1 and 800mg· L-1 decreased the slope of phase 4 of action Potentials of isolated sinoatrial node in rabbits, decreased the rate of action potential phase 0 depolarization and the amplitude of the action potential in sinoatrial node, PQS 200mg·L-1 markedly decreased the frequencydependent positive staircase phenomenon of isolated guinea pig atrium. The results suggest that the electrophysiological effects of PQS may be related to a blockage of the cation currents of Ca2+in myocardial cells. |
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| Keywords: | panax quinquefolium saponin rabbit sinoatrial node guinea pig atrium |
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