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~(60)Co射线放疗前后癌症患者外周血淋巴细胞染色体畸变频率
引用本文:偶晓明,郭士雄,关连璞. ~(60)Co射线放疗前后癌症患者外周血淋巴细胞染色体畸变频率[J]. 西安交通大学学报(医学版), 1991, 0(1)
作者姓名:偶晓明  郭士雄  关连璞
作者单位:西安医科大学生物学教研室(偶晓明,郭士雄),西安医科大学生物学教研室(关连璞)
摘    要:本文以50例正常人为对照组与50例食道癌、宫颈癌患者和30例经~(60)Co射线放疗的癌症患者外周血淋巴细胞的染色体畸变率(CAs)进行了比较研究。发现放疗前患者的CAs比正常人明显升高,而放疗后的患者,CAs又明显高于放疗前的患者,这些都说明了CAs不仅可作为癌症患者的细胞遗传标记物,而且也能检测由~(60)Co射线所诱导的遗传学效应。肿瘤的发生和射线的局部照射同样影响了患者的外周血淋巴细胞。

关 键 词:~(60)Co射线  放射治疗  癌症  淋巴细胞  染色体畸变

STUDY ON FREQUENCIES OF CHROMOSOMAL ABERRATIONS IN PERIPHERAL LYMPHOCYTES FROM CANCER PATIENTS BEFORE AND AFTER ~(60)-RAY RADIOTHERAPY
Ou Xiaoming,Guo Shixiong,Guan Lianpu. STUDY ON FREQUENCIES OF CHROMOSOMAL ABERRATIONS IN PERIPHERAL LYMPHOCYTES FROM CANCER PATIENTS BEFORE AND AFTER ~(60)-RAY RADIOTHERAPY[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1991, 0(1)
Authors:Ou Xiaoming  Guo Shixiong  Guan Lianpu
Affiliation:Ou Xiaoming;Guo Shixiong;Guan Lianpu Department of Biology
Abstract:The frequencies of chromosomal aberrations (CAs)were studied comparatively in peripheral lymphocytesfrom 50 normal controls, 50 patients with cervicalcarcinoma and esophageal cancer, and 30 patients withcencers after ~(60)Co--ray radiotherapy, There was a high-ly significant increased frequency of CAs in patientswith cancers before radiotherapy to normal controls,the patients with cancers after radiotherapy had an obvi-ous increase in frequency of CAs compared with thosebefore radiotherapy. The results showed that the CAsnot only is a genetic marker in patients with cancers,but also may be useful for measuring effects on geneticmaterial induced by ~(60)Co--ray. The carcinogencsis andlocal irradiation could affect peripheral lymphcytes of pa-tients with cancers.
Keywords:~(60)Co-ray   radiotherapy   cancer   lymphocytes  chromosomal aberrations
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