| 大鼠心肌梗塞后心肌肥大早期心肌肌球蛋白ATP酶活性及同功酶的变化 |
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| 引用本文： | 陈月,雷立权,卢兴,邹丽容.大鼠心肌梗塞后心肌肥大早期心肌肌球蛋白ATP酶活性及同功酶的变化[J].西安交通大学学报(医学版),1990(2). |
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| 作者姓名： | 陈月 雷立权 卢兴 邹丽容 |
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| 作者单位： | 西安医科大学病理生理学教研室
(陈月，雷立权，卢兴)，西安医科大学病理生理学教研室(邹丽容) |
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| 摘 要： | 为探讨心肌梗塞(MI)后心肌肥大早期肌球蛋白ATP酶活性和同功酶的变化及其意义,本文用大鼠MI模型,于术后第9天和第21天分别测定了非梗塞心肌肌球蛋白ATP酶活性、同功酶分布及心肌细胞直径。结果表明,MI后第9天,在心肌细胞直径增大的同时,肌球蛋白ATP酶活性下降,同功酶V_1含量下降。至MI后第21天,上述这种变化更加明显。结果提示:MI早期随着非梗塞心肌肥大的建立,肌球蛋白ATP酶活性及其同功酶分布也发生了适应性的改变。
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| 关 键 词： | 心肌梗塞 肌球蛋白ATP酶 同功酶 |
THE CHANGES OF MYOSIN ATPase ACTIVITY AND ITS ISOENZYME DISTRIBUTION IN EARLY STAGE OF CARDIAC HYPERTROPHY FOLLOWING MYOCARDIAL INFARCTION IN RATS |
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| Chen Yue,et al.THE CHANGES OF MYOSIN ATPase ACTIVITY AND ITS ISOENZYME DISTRIBUTION IN EARLY STAGE OF CARDIAC HYPERTROPHY FOLLOWING MYOCARDIAL INFARCTION IN RATS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(2). |
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| Authors: | Chen Yue |
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| Institution: | Department of pathophysiology |
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| Abstract: | To investigate the changes of cardiac myosin ATPase and its isoenzyme in early stage of cardiac hypertrophy following myocardial infarction(MI), we studied myosin ATPase activitzy, isoenyme distriibution and myocardial fiber diameter of uninfarcted ventricu lar sfptum, 9 aed 21 days after operation in MI rats. The results showed that coincident with the increases in myocardial fiber diameter on 9 days after MI, both myosin ATPase activity and V_1 isoenzyme amount were depressed. These changes were more pronounced on 21 after MI. It is suggested that with the development of myocardial hypertrophy in early stage of MI, adaptive changes in myosin ATPase activity and isoenzyme distribution occur. |
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| Keywords: | myodardial infarction myosin ATPase isoenzyme |
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