| 泼尼松龙对脂多糖诱导的RANTES的影响 |
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| 引用本文： | 朴花子,张成镐,方宇辉.泼尼松龙对脂多糖诱导的RANTES的影响[J].西安交通大学学报(医学版),2007,28(1):28-30. |
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| 作者姓名： | 朴花子 张成镐 方宇辉 |
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| 作者单位： | 延边大学基础医学院机能实验学教研室,吉林延吉,133000 |
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| 摘 要： | 目的探讨泼尼松龙对脂多糖(LPS)诱导的小胶质细胞激活时所分泌的趋化因子RANTES的影响。方法采用MEM培养液培养小胶质细胞,培养液中添加不同质量浓度的LPS(0、100、500、1 000μg/L)及LPS(100μg/L)与10μmol/L的泼尼松龙后再培养12 h,用ELISA法测定细胞外液所分泌的RANTES含量。结果LPS能高度激活小胶质细胞并且能使RANTES分泌增加,泼尼松龙明显抑制RANTES的含量。结论泼尼松龙有抑制趋化因子RANTES的分泌作用。
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| 关 键 词： | 泼尼松龙 小胶质细胞 RANTES 脂多糖 |
| 文章编号： | 1671-8259(2007)01-0028-03 |
| 修稿时间： | 2006-04-04 |
Effect of prednisolone on LPS-induced RANTES production |
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| Piao Huazi,Zhang Chenggao,Fang Yuhui.Effect of prednisolone on LPS-induced RANTES production[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2007,28(1):28-30. |
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| Authors: | Piao Huazi Zhang Chenggao Fang Yuhui |
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| Institution: | Department of Functional Experimental Science, Yanbian University College of Basic Medicine, Yanji 133000, China |
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| Abstract: | Objective To study the effect of prodnisolone on lipopolysaccharide(LPS)-induced RANTES by microglia.Methods The microglia were incubated in MEM culture medium,and different concentrations of LPS 0,100,500,1000μg/L) or LPS(100μg/L) and prodnisolone(10μmol/L) were added into the culture medium.12h later,the amount of RANTES was measured by ELISA.Results Microglia markedly produced RANTES in response to LPS.Prodnisolone significantly reduced the production of RANTES in microglia.Conclusion Prodnisolone has an inhibitive effect on the production of chemokines such as RANTES. |
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| Keywords: | RANTES |
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