| 平阳霉素局部注射对鼻息肉病息肉组织病理学的影响 |
| |
| 引用本文： | 杨妙丽,张向红,邹纪东,李宝树,任晓勇,石季.平阳霉素局部注射对鼻息肉病息肉组织病理学的影响[J].西安交通大学学报(医学版),2007,28(5):589-591. |
| |
| 作者姓名： | 杨妙丽 张向红 邹纪东 李宝树 任晓勇 石季 |
| |
| 作者单位： | 1. 西安交通大学医学院第二附属医院耳鼻咽喉科,陕西西安,710004
2. 山东省人民医院耳鼻咽喉科,山东济南,250012 |
| |
| 摘 要： | 目的通过观察平阳霉素治疗前后鼻息肉病息肉组织的病理变化情况,探讨平阳霉素治疗鼻息肉病的机制。方法应用末端脱氧核苷酸转移酶介导的脱氧三磷酸尿苷缺口末端标记法(TUNEL法)检测凋亡细胞,与相邻连续的HE染色片对位对照观察嗜酸性粒细胞的凋亡情况。结果平阳霉素治疗前鼻息肉组织嗜酸性粒细胞表达显著高于正常下鼻甲(P<0.01);治疗后鼻息肉组织中的嗜酸性粒细胞表达明显低于治疗前(P<0.01);治疗后鼻息肉组织中嗜酸性粒细胞的凋亡指数高于治疗前(P<0.01)。结论嗜酸性粒细胞是鼻息肉病息肉组织中主要的浸润炎细胞;平阳霉素可通过促进嗜酸性粒细胞凋亡达到治疗鼻息肉病的目的。
|
| 关 键 词： | 平阳霉素 鼻息肉病 病理学影响 |
| 文章编号： | 1671-8259（2007）05-0589-03 |
| 修稿时间： | 2007-03-18 |
Pathological effects on nasal polyposis tissue after bleomycin A5 local injection |
| |
| Yang Miaoli,Zhang Xianghong,Zou Jidong,Li Baoshu,Ren Xiaoyong,Shi Ji.Pathological effects on nasal polyposis tissue after bleomycin A5 local injection[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2007,28(5):589-591. |
| |
| Authors: | Yang Miaoli Zhang Xianghong Zou Jidong Li Baoshu Ren Xiaoyong Shi Ji |
| |
| Abstract: | Objective To study the pathological effects on nasal polyposis tissue after bleomycin A5 local injection.Methods Totally 119 cases of nasal polyposis specimen obtained before and after treatment with bleomycin A5 were studied with terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling(TUNEL).Results The number of eosinophils in nasal polyposis specimen before treatment was significantly higher than that after treatment(P<0.01) and normal inferior turbinate concha mucosa(P<0.01).The apoptosis index(AI) of eosinophil after treatment was significantly higher than that before treatment(P<0.01).Conclusion Eosinophil is the main infiltration cell in nasal polyposis tissue.Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis. |
| |
| Keywords: | bleomycin A5 nasal polyposis pathological effect |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
