| 两种四环素胶囊剂的溶出度及生物利用度的研究 |
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| 引用本文： | 安彩贤,丰艳梅.两种四环素胶囊剂的溶出度及生物利用度的研究[J].西安交通大学学报(医学版),1991(4). |
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| 作者姓名： | 安彩贤 丰艳梅 |
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| 作者单位： | 西安医科大学药学系药剂教研室
(安彩贤)，西安医科大学第二附属医院药剂科(丰艳梅) |
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| 摘 要： | 通过对四环素碱胶囊剂和盐酸四环素胶囊剂溶出度及体内生物利用度的测定,表明四环素碱胶囊剂的溶出度低于盐酸四环素胶囊,但在生物利用度方面却优于后者。溶出度和生物利用度之间没有显著相关性。对于四环素碱和盐酸四环素来说,生物利用度不完全取决于溶出度,还与其在体内的吸收特性有关。所以,四环素碱胶囊剂以其价廉、生物利用度高的优点,有着广泛的临床价值。
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| 关 键 词： | 生物利用度 胶囊剂 溶出度 四环素碱 盐酸四环素 |
THE DISSOLUTION RATES AND BIOAVAILABILITIES OF TETRACYCLINE HYDROCHLORIDE CAPSULES AND TETRACYCLINE CAPSULES |
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| An Caixian,Feng Yanmei.THE DISSOLUTION RATES AND BIOAVAILABILITIES OF TETRACYCLINE HYDROCHLORIDE CAPSULES AND TETRACYCLINE CAPSULES[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1991(4). |
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| Authors: | An Caixian Feng Yanmei |
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| Institution: | An Caixian,Feng Yanmei Department of pharmaceutics,Xian Medical University |
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| Abstract: | The dissolution rates and bioavailabilities oftetracycline capsules and tetracycline hydrochloride cap-sules were determined. The results showed that the dis-solution rate of tetracycline capsules was lower thantetracycline hydrochloride capsules, but it was superior inbioavailability. The correlation between bioavailabilitiesand dissolution rates was not significant. Fortetracycline and tetracycline hydrochlocride thebioacailabilities were not completely dependent on thedissolution rates, and were related to their absorbingcharacters. So the tetracycline capsules still had a wideclinical use for its more inexpersive cost and higherbicavailability. |
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| Keywords: | bioavailabilily capsules dissolution rate tetracycline tetracycline hydrochloride |
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