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| 阿司匹林对衰老模型大鼠学习记忆能力的影响 | |
| 引用本文： | 巩睿智,陈丽,魏涛,余玲,杨璠,李伟,张仑,宋燕州,王兴会.阿司匹林对衰老模型大鼠学习记忆能力的影响[J].西安交通大学学报(医学版),2011,32(2):184-186. |
| 作者姓名： | 巩睿智 陈丽 魏涛 余玲 杨璠 李伟 张仑 宋燕州 王兴会 |
| 作者单位： | 1. 西安交通大学医学院,第一附属医院临床医学系,陕西西安,710061 2. 西安交通大学医学院,生理学与病理生理学系,陕西西安,710061 3. 西安交通大学医学院,机能教学实验中心,陕西西安,710061 |
| 基金项目： | 国家级大学生创新性实验计划项目(No.091069836)~~ |
| 摘 要： | 目的观察阿司匹林对衰老模型大鼠学习记忆能力的影响。方法采用皮下注射D-半乳糖生理盐水溶液制备衰老大鼠模型。不同剂量阿司匹林以及阳性治疗药物处理后,采用Morris水迷宫行为检测方法观察大鼠学习记忆能力。结果与未治疗的衰老模型大鼠相比,小、中剂量阿司匹林应用后,大鼠平均逃避潜伏期明显缩短,穿越站台的次数显著增加;而大剂量阿司匹林处理大鼠的逃避潜伏期和穿越站台次数均无明显变化。结论适当剂量的阿司匹林能够改善衰老模型大鼠的学习记忆能力,而大剂量阿司匹林反而加剧衰老模型大鼠的精神症状。 |
| 关 键 词： | 阿司匹林 衰老模型 学习记忆 Morris水迷宫 |
Effects of aspirin on spatial learning and memory in aging rat model |
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| GONG Rui-zhi,CHEN Li,WEI Tao,YU Ling,YANG Fan,LI Wei,ZHANG Lun,SONG Yan-zhou,WANG Xing-hui.Effects of aspirin on spatial learning and memory in aging rat model[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(2):184-186. | |
| Authors: | GONG Rui-zhi CHEN Li WEI Tao YU Ling YANG Fan LI Wei ZHANG Lun SONG Yan-zhou WANG Xing-hui |
| Institution: | GONG Rui-zhi1,CHEN Li2,WEI Tao1,YU Ling1,YANG Fan1,LI Wei1,ZHANG Lun1,SONG Yan-zhou1,WANG Xing-hui3(1.Department of Clinical Medicine,the First Affiliated Hospital,2.Department ofPhysiology and Pathophysiology,3.Teaching Center of Functional Experiment,Medical School of Xi'an Jiaotong University,Xi'an 710061,China) |
| Abstract: | Objective To observe the effects of aspirin on spatial learning and memory in aging rat model.Methods D-galactose was injected subcutaneously once per day to prepare the aging rat models.After administration of aspirin or therapeutic drug,Morris water maze was used to examine the capability of learning and memory by detecting the mean latencies and the times to cross the target.Results Small and medium doses of aspirin decreased the mean latencies and increased the times to cross the target of aging rats.Ho... |
| Keywords: | aspirin aging model learning and memory Morris water maze |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |