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| 常量硫酸镁治疗重型颅脑损伤的临床研究 | |
| 引用本文： | 何百祥,丁丽,张志峰,鲍刚,汪鑫,李瑞春,张瑞娟.常量硫酸镁治疗重型颅脑损伤的临床研究[J].西安交通大学学报(医学版),2011,32(2):226-229. |
| 作者姓名： | 何百祥 丁丽 张志峰 鲍刚 汪鑫 李瑞春 张瑞娟 |
| 作者单位： | 1. 西安交通大学医学院,第一附属医院神经外科,陕西西安,710061 2. 安交通大学医学院,第一附属医院检验科,陕西西安,710061 3. 西安交通大学医学院,公共卫生系营养与食品卫生学教研室,陕西西安,710061 |
| 基金项目： | 陕西省卫生厅科研基金资助项目(No.08H30)~~ |
| 摘 要： | 目的探讨常量硫酸镁治疗重型颅脑损伤(sTBI)的临床效果、用药方案及其安全性。方法将入选病例随机分为治疗组和对照组,每组30例。对照组按常规治疗,治疗组加用常量硫酸镁。正常组20例,为成年健康献血员。按预设时间抽取肘静脉血,采用原子分光光度法测定血清Mg2+浓度。患者入院时、入院2周分别记录GCS评分。3月随访记录GOS评级并量化评分。观察记录治疗组和对照组患者伤后5 d的不良反应情况。应用SPSS13.0软件包分析数据。结果 sTBI后对照组患者血清Mg2+浓度立即下降,24 h内最低,7~14 d基本正常。治疗组患者伤后2~3 d血清Mg2+浓度明显高于对照组(P<0.01),7~14 d基本下降至正常。患者治疗2周后的GCS评分比较,治疗组高于对照组(P<0.05)。3月GOS评分治疗组高于对照组,但差异无统计学意义。治疗组和对照组患者sTBI后5 d内出现的不良反应比较,差异无统计学意义。结论常量硫酸镁治疗sTBI的近期疗效良好;伤后24 h内用药、连用5 d的用药方案是科学、有效、安全的。 |
| 关 键 词： | 重型颅脑损伤 镁离子 常规剂量 临床效果 不良反应 |
Clinical study on routine-dose magnesium sulfate treatment in patients with severe traumatic brain injury |
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| HE Bai-xiang,DING Li,ZHANG Zhi-feng,BAO Gang,WANG Xin,LI Rui-chun,ZHANG Rui-juan.Clinical study on routine-dose magnesium sulfate treatment in patients with severe traumatic brain injury[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(2):226-229. | |
| Authors: | HE Bai-xiang DING Li ZHANG Zhi-feng BAO Gang WANG Xin LI Rui-chun ZHANG Rui-juan |
| Institution: | HE Bai-xiang1,DING Li2,ZHANG Zhi-feng3,BAO Gang1,WANG Xin1,LI Rui-chun1,ZHANG Rui-juan3(1.Department of Neurosurgery,the First Affiliated Hospital,2.Department ofClinical Laboratory,3.Department of Nutriology andFood Sanitation,Medical School of Xi'an Jiaotong University,Xi'an 710061,China) |
| Abstract: | Objective To investigate the clinical efficacy,protocol and safety of routine-dose magnesium sulfate treatment in patients with severe traumatic brain injury(sTBI).Methods The enrolled patients were randomly assigned to experimental group and control group,30 in each group.Patients in control group were treated with conventional therapy while those in experimental group were treated with routine-dose magnesium sulfate apart from conventional therapy.Normal group consisted of 20 healthy adult blood donors.We... |
| Keywords: | severe traumatic brain injury magnesium ion routine dose clinical efficacy adverse resection |
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