|
|||||
|
|
| 癫痫模型大鼠动情周期及卵巢形态学的改变 | |
| 引用本文： | 潘娟,张灵武,王峰,孙涛.癫痫模型大鼠动情周期及卵巢形态学的改变[J].西安交通大学学报(医学版),2011,32(2):165-169. |
| 作者姓名： | 潘娟 张灵武 王峰 孙涛 |
| 作者单位： | 1. 宁夏医科大学,研究生学院,宁夏银川,750004 2. 宁夏医科大学,附属医院妇产科,宁夏银川,750004 3. 宁夏医科大学,附属医院神经外科,宁夏银川,750004 4. 宁夏医科大学,宁夏回族自治区颅脑疾病重点实验室,宁夏银川,750004 |
| 基金项目： | 国家自然科学基金项目资助(No.30750014)~~ |
| 摘 要： | 目的探讨大鼠动情周期及卵巢形态学在杏仁核电刺激点燃的癫痫模型中的变化。方法 35只8周龄SD雌性大鼠,随机分为癫痫模型组(n=15)、假手术组(n=10)和对照组(n=10)。癫痫模型组,双极电极植入大鼠左侧杏仁基底外侧核,给予连续电刺激,建立电点燃的癫痫模型;假手术组,电极植入后不给予电刺激;对照组为正常雌性大鼠。所有大鼠每天清晨行阴道细胞涂片,以监测动情周期。癫痫模型大鼠在点燃20 d后于动情周期的间期取右侧卵巢组织,同期其他两组大鼠也分别于动情间期摘取右侧卵巢组织,制作病理切片,HE染色后镜下阅片,采用Image-ProPlus 6.0分析软件进行形态学分析。结果癫痫模型大鼠失去正常动情周期,日均体重获得及卵巢重量均较假手术组及对照组显著增高(P<0.05);病理显示,癫痫模型组大鼠卵巢中窦前卵泡、总卵泡数及闭锁卵泡显著增多(P<0.05),卵巢发生多囊性改变。结论癫痫发作可影响大鼠排卵功能,并导致大鼠发生卵巢多囊性改变。 |
| 关 键 词： | 动情周期 卵巢形态学 癫痫点燃模型 多囊卵巢 |
Changes of estrous cycle and ovarian morphology in amygdale-kindled seizures female rats |
|
| PAN Juan,ZHANG Ling-wu,WANG Feng,SUN Tao.Changes of estrous cycle and ovarian morphology in amygdale-kindled seizures female rats[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(2):165-169. | |
| Authors: | PAN Juan ZHANG Ling-wu WANG Feng SUN Tao |
| Institution: | PAN Juan1,ZHANG Ling-wu2,WANG Feng3,SUN Tao3(1.Graduate School,Ningxia Medical University,2.Department of Gynecology & Obstetrics ofthe Affiliated Hospital,3.Department of Neurosurgery of the Affiliated Hospital,4.Key Lab of Craniocerebral Disease ofNingxia Hui Autonomons Region,Yinchuan 750004,China) |
| Abstract: | Objective To explore changes of estrous cycle and ovarian morphology in amygdale-kindled seizures female rats.Methods Thirty-five SD female rats aged 8 weeks were randomly divided into epilepsy model(n=15),sham-operation(n=10) and control groups(n=10).Kindling electrodes were implanted in the left basolateral amygdala in the female rats of model group.The rats were kindled by brief,daily,suprathreshold stimulations with a bipolar electrode.The sham-kindled rats only had bipolar electrode implanted in the le... |
| Keywords: | estrus cycle ovarian morphology kindling model polycystic ovary |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |