肝硬变状态下胆石发生机理的实验研究

采用四氯化碳灌胃方法制成豚鼠肝硬变模型。通过观察豚鼠胆囊结石形成．扫描电镜观察胆石细微结构，并结合豚鼠肝脏及胆囊超微结构变化及胆囊胆汁结合胆汁酸簿层色谱扫描定量测定，以探讨肝硬变状态下胆石发生机理。结果显示各组动物胆石发生率：对照组5％，慢性肝损害组37．5％，肝硬变组83．3％。胆囊胆汁中结合胆汁酸：慢性肝损害组及肝硬变组均明显低于对照组，以肝硬变组下降最为明显。结果表明：肝硬变状态下结合胆汁酸含量下降，胆石发生率明显增高。

THE MECHANISM OF GALLSTONE FORMATION IN LIVER CIRRHOSIS

In order to study the mechanism ofgallstone formation in liver cirrhosis, we establisheda cirrhotic model in guinea pigs induced by CCI4.First, we observed gallstone formation. Second, weobserved microstructure of gallstone under scanning electromicroscope. Third. we observed nit rastrllcture of liver and gallbladder under transmision electromicroscope. And lastly.we measured conjugated bile acids of gallbladder bile. Experiment results showed that the gallstone formation rate in conrtol group was 5%,while those in chronic liver damage and cirrhotic group were 37. 5% and 83. 3% respectively. The level of conjugated bile acid of gallbladder bile decreased in chronic liver damage .and cirrhotic group and G/T ratio showed the similar trend.