低硒儿童的肌肉代谢

本文从五个方面对环境因子(低硒)与低硒儿童肌肉代谢之间的关系作了较为系统的病因学研究,根据研究结果,我们已初步形成一个关于低硒可引起儿童肌细胞线粒体能量代谢障碍的学说。该学说主要认为(1)硒是人类肌肉代谢的必须微量元素;(2)低硒不同水平对肌肉代谢具有不同影响,一般可分为两个等级即一般和严重缺硒;(3)低硒可影响线粒体ATP和肌酸合成代谢,减少磷酸肌酸的合成率,并可导致线粒体结构损害以及(4)初步确立儿童每日硒摄入量的最低标准。基于上述结果,我们还建议对低硒儿童中出现的骨骼肌萎缩可命名为“地方性硒反应性肌营养不良症”。

MUSCULAR METABOLISM IN LOW SE CHILDREN

A series of etiological investigations were made on muscular metabolism in low Se children and rats, including (1) low Se environment and low Se state in children, (2) moasurement of some biochemical indexes concerning muscular metabolism (selenium, creatine, ereatinine, phosphate, CPK, etc.), (3) Se supplemented experiment on children in low Se state, (4) experimental study on Se deficiency and Se supplemented dietary in rats, (5) patho-histological findings on the muscular tissues of children with KBD, and (6) effect of Se deficiency on muscular metabolism in children. The results show that there may be a causal relationship between Se deficiency in environment and muscular metabolism di- sturbance in low Se children. A hyphothesis on the disturbance of energy metabolism in mitochondria caused by Se deficiency is put forward that Se deficiency may blunt creatinephosphate synthesis in mitochondria and cause lesions in the mitochondrial structure, which was different from the antioxidant fiction. There is a marginal deficiency in Se for children in this paper, i.e. to take more than 20 μtg Se/day is necessary. We suggest that muscular atrophy in low Se children be precisely designated by the name of "endemic Seresponsive muscular dystrophy".