功能性消化不良与十二指肠胃反流关系的研究

目的研究功能性消化不良(FD)与十二指肠胃反流(DGR)的关系。方法对20例健康对照者和22例FD患者进行胃内pH和Bilitec 2000同步监测,并对FD患者DGR症状进行评分,研究DGR症状与胃内pH≥4及胆红素吸光值(Abs)≥0.14总时间百分比的关系。结果FD组餐后期pH≥4时间(%)和Abs≥0.14时间(%)明显高于正常组,分别为45.78±22.54和23.69±17.26,45.12±25.31和23.97±18.54,有显著性差异,P均<0.05。两组夜间胃内pH≥4和Abs≥0.14出现例数(%)、总持续时间(min)、反流次数、反流>5 min次数及最长反流时间无显著性差异。上腹痛症状评分(SS)与胃内pH≥4总时间%存在相关关系,r=0.678,P<0.01;呕吐胆汁SS与胃内Abs≥0.14总时间%存在相关关系,r=0.495,P<0.05。结论DGR在FD发生中起一定作用。

Relationship between functional dyspepsia and duodenogastric reflux

Objective To study the relationship between functional dyspepsia(FD) and duodenogastric reflux(DGR).Methods Simultaneous 24-hour ambulatory intragastric pH and bilirubin concentration monitoring(Bilitec 2000) were performed in 20 healthy controls and 22 FD patients.For each patient,symptoms associated with alkaline and bile reflux score(SS) were calculated.The correlation between SS and and the percentage of the time pH≥4 of total time,SS and the percentage of the time Abs≥0.14 of total time were analyzed.Results The percentage of the time pH≥4 and Abs≥0.14 of post-prandial periods was higher in FD patients than in normal controls,45.78±22.54 vs.23.69±17.26,45.12±25.31 vs.23.97±18.54,respectively(P<0.05).Rank correlation analysis showed a correlation between epigastric pain SS and the percentage of the time pH≥4 of total time(r=0.678,P<0.01),vomiting bile SS and the percentage of the time Abs≥0.14 of total time(r=0.495,P<0.05).Conclusion DGR may play a role in FD.