多抗甲素对S_（180）荷瘤小鼠红细胞免疫功能的影响

用动物实验方法建立Ｓ１８０荷瘤小鼠模型，观察荷瘤小鼠红细胞免疫功能的改变及多抗甲素对Ｓ１８０小鼠红细胞免疫功能的影响。结果发现：①荷瘤小鼠ＲＢＣ－Ｃ３ｂ受体花环率下降，ＲＢＣ－ＩＣ花环率上升；血清中ＲＢＣ－Ｃ３ｂ受体免疫粘附促进因子活性下降，而抑制因子活性上升。②多抗甲素治疗后，荷瘤小鼠ＲＢＣ－Ｃ３ｂ受体花环率、ＲＢＣ－ＩＣ花环率均明显上升；血清中ＲＢＣ－Ｃ３ｂ受体免疫粘附促进因子活性上升，抑制因子活性下降。提示红细胞免疫功能的检测可作为肿瘤发生发展的指标之一，多抗甲素可恢复和提高荷瘤机体的红细胞免疫功能。

EFFECT OF POLYACTIN A ON RED CELL IMMUNE FUNCTION OF S_(180) BEARING MICE

In this study, animal test methods were used to establish Sarcomaia180(S180) bearing mice model, and the change of red immune function and polyactin A treatment effect are observed. The results showed that the RBC-C3b receptor rosette rate of the tumor bearing mice decreased and the RBC-IC rosette rate increased; the serum RBC-C3b receptor immune adherence enhancement factor activity decreased and inhibitory factor activity increased. After polyactin A treatment, the RBC3b receptor rosette rate and RBC-IC rosette rate increased; the serum RBC-C3b receptor immune adherence enhancement factor activity increased and inbibitory factor activity decreased. This suggests that the assay of the red immune function can be used as one of indexes of the tumor genesis and development , and polyactin A has the obvious effect of enhancing and recovering the red cell immune function of the S180 bearing body.