| 胶束荧光法对兔血浆中胺碘酮药代动力学的研究 |
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| 引用本文： | 庞志功,汪宝琪,武国杰,高连洪.胶束荧光法对兔血浆中胺碘酮药代动力学的研究[J].西安交通大学学报(医学版),1992(4). |
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| 作者姓名： | 庞志功 汪宝琪 武国杰 高连洪 |
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| 作者单位： | 西安医科大学药学系分析化学教研室，西安医科大学无机化学教研室，西安医科大学第二附属医院临床药理研究室，陕西省医药工业研究所 西安 710061，710032 |
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| 摘 要： | 利用具有高灵敏度的胶束荧光法,对胺碘酮的血药浓度进行了监测;使用SLS为胶束试剂,以国产930型荧光光度计为主要分析仪器,得到系列药代动力学参数:t_(1/2)(α)为1.18h,t_(1/2)(β)为40.75h,K_(21)为0.278h~(-1),K_(10)为0.036h~(-1),K_(12)为0.291h~(-1)。该法的线性范围为2×10~(-9)～8×10~(-6)mol/L,检测限为1.3×10~(-9)mol/L,平均回收率为99.93%。
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| 关 键 词： | 胶束荧光 胺碘酮 药代动力学 |
STUDY ON PHARMACOKINETIOS OF AMIODARONE IN RABBIT PLASTER BY MICELLAR ENHARCED FLUORIMETRIC METHOD |
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| Pang Zhigong,Wang Baoqi,Wu Guojie.STUDY ON PHARMACOKINETIOS OF AMIODARONE IN RABBIT PLASTER BY MICELLAR ENHARCED FLUORIMETRIC METHOD[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(4). |
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| Authors: | Pang Zhigong Wang Baoqi Wu Guojie |
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| Abstract: | The authors used high sensitive micellar enhanced fluorimetric method to monitor amiodarone blood-medical concentration. SLS severed as micellar reagent. Under experimental condition,we used 930 fluorophotommeter which made in China as the main analytic instrument,and obtained a series pharmacokinetic parameter ,eg. t_(1/2) (α) was 1.18 h, t_(1/2)(β)was 40.75 h, K_(21) was 0.278 l/h,K_(10) was 0.036 l/h,K_(12) was 0.291 l/h. The linear range of this method was 2 × 10_(-9)～8 × 10_(-6) mol/L,determined limit was 1.3 × 10~(-9)mol/L, average recovery was 99.93%. |
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| Keywords: | mieellar enhanched fluorimetry amiodarone pharmacokinetics |
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