| T_3核受体各亚型mRNA在不同甲状腺功能患者外周血白细胞中的表达 |
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| 引用本文： | 王莉,朱本章,雒文田.T_3核受体各亚型mRNA在不同甲状腺功能患者外周血白细胞中的表达[J].西安交通大学学报(医学版),2001,22(1). |
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| 作者姓名： | 王莉 朱本章 雒文田 |
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| 作者单位： | 1. 西京医院内分泌科
2. 西安交通大学内分泌代谢病研究室, |
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| 基金项目： | 卫生部直属单位临床学科重点项目![2 2 (0 5 5 ) ] |
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| 摘 要： | 目的 T3对细胞的代谢调节作用是通过甲状腺激素核受体 (T3R)介导的 ,细胞中T3R量与细胞对T3的反应性有关。本文探讨了T3R表达与人体不同甲功状态的关系。方法 应用半定量RT PCR法 ,研究了Graves 甲亢、桥本甲炎甲功正常、桥本甲炎甲减患者外周血白细胞中T3R各亚型mRNA表达量的变化 ,并与正常对照进行比较。结果 外周血白细胞中T3Rα1 、T3Rα2 、T3Rβ2 mRNA表达在Graves 甲亢患者降低 ,在桥本甲炎甲减患者升高 ,而桥本甲炎甲功正常者有升高倾向 ;T3Rβ1 mRNA在不同甲功状态中变化不大。结论 在外周血白细胞中 ,T3RmRNA各亚型表达与甲功状态密切相关 ,T3对其受体亚型mRNA表达水平有下调作用 ,但T3Rβ1 mRNA表达不受甲功状态影响。
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| 关 键 词： | T_3核受体 Graves甲亢 桥本甲炎 |
Expression of thyroid hormone receptor mRNAs in peripheral leukocytes in different thyroid states |
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| Abstract: | Objective The metabolic effects of T3 are mediated by binding toits nuclear receptors(T3Rs). The relationship between the T3Rs mRNA expression and different thyroid states was discussed.Methods By using Semiquantitative RT-PCR method, the researchers examined T3R mRNAs level in peripheral leukocytes of Graves disease (GD), Hashimoto thyroiditis(TH) with euthyroidism, Hashimoto thyroiditis with hypothyroidism and normal controls. Results T3Rα1, T3Rα2, T3Rβ2 mRNA levels were all decreased in GD patients, while increased in HT with hypothyroidism. Conclusion They all was tend to increase in HT with euthyroidism. T3Rβ1 mRNA level was no major difference in each group. |
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| Keywords: | triiodothyronine(T 3) T 3 nuclear receptor Graves' disease(GD) Hashimoto thyroiditis(HT) |
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