| Sirtuin Functions in the Brain：From Physiological to Pathological Aspects |
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| 引用本文： | 邵家骧,;张婷婷,;刘腾远,;全亦周,;李凡,;刘杰,;杨霄,;谢谦,;夏伟梁.Sirtuin Functions in the Brain：From Physiological to Pathological Aspects[J].上海交通大学学报(英文版),2014(6):651-662. |
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| 作者姓名： | 邵家骧 ;张婷婷 ;刘腾远 ;全亦周 ;李凡 ;刘杰 ;杨霄 ;谢谦 ;夏伟梁 |
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| 基金项目： | the National Natural Science Foundation of China（No.31270032）; the Shanghai Jiao Tong University Interdisciplinary Research Grant（No.YG2012ZD05）; the Grant from Ministry of Science and Technology of China（No.2013CB945604）
Acknowledgement The authors would like to thank Prof. YANG Guo-yuan for his help in stroke models and Prof. GAO Wei-qiang for his help in stem cell studies. |
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| 摘 要： | Sirtuins are a family of nicotinamide adenine dinucleotide(NAD+) dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals,there are seven members(Sirt1—Sirt7), with diversities in their subcellular localizations and enzymatic activities.Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer's, Parkinson's, and motor neuron dysfunction.Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.
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| 关 键 词： | sirtuin neural development hypothalamic function stroke neurodegeneration |
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