THE CLINICAL SIGNIFICANCE OF TSAb IN GRAVES' DISEASE

ＧａｏＨｕｔ（高慧）；ＪｉｎＳｈｉｘｉｎ（金世鑫）；ＺｏｎｇＪｉａｎｑｉ（宗建奇）；ＬｉＪｉａｎ（李健）；ＭａＸｉｕｐｉｎｇ（马秀萍）；ＳｈｉＢｉｎｇｙｉｎ（施秉银）ＴＨＥＣＬＩＮＩＣＡＬＳＩＧＮＩＦＩＣＡＮＣＥＯＦＴＳＡｂＩＮＧＲＡＶＥＳ＇ＤＩＳＥ...

THE CLINICAL SIGNIFICANCE OF TSAb IN GRAVES'DISEASE

TSAb and TSBAb both were measured in i63 patients with Graves' disease(GD) and 31 Autoimmune Thyroiditis(AIT) individually and simultaneously. The TSAb activities and positive percentage in active and relapse GD groups were higher than those in the normal control and euthyroidgroups; no significant difference was found between the active GD and relapse GD groups. TSAb were positive in one of 31 Patients with hypothyroidism due to AIT. TSBAb were positive in GD patients after treatment who became patients with hypothyroidism and patients with bypothyroidism dueto AIT, being 30. 0% and 35.5% respectively. TSAb and TSBAb were measured simultaneously in 35GD patients with different thyroid function status, and 4 PatientS with hypothyroidism due to AIT.We found that two patients with GD who were euthyroid during treatment with ATD and one patient with active GD had TSAb and TSBAb coexisting in circulation. we would postulate that perhaps only one kind of preponderant autoantibody activity could be detected and those nonpreponderant autoantibodies might be very difficultly found, when the patients were in a certain stable thyroid function saute.