| THE RELATIONSHIP OF p53 GENE MUTATION AND TUMORINVASION AND LYMPH NODE METASTASIS IN EARLY GASTRIC CANCER |
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| 作者姓名： | 徐威 车向明 |
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| 作者单位： | Department of Immunopathology，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | Thehumanp53gene,locatedonchromosome17pl3,isanimportanttumorsuppressorgenewhosefunctionistopreventtumorigenesis.Recentstudiessuggestedthatp53genecanstartapoptosisofcellsincertaincircumstancestl).p53geneisconsideredtobeinvolvedincarcinogenesisofmanyorgans.Recently,concerningp53geneingastriccanceranditsrelationwithpathologyorprognosis,numbersofinvestigationshavebeenreportedandtheresultswerevarious(2'3).butfewstudiesconcerneditsrelationshipwithtumorinva.sionandlymphnodemetastasisinearlygastriccanc…
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THE RELATIONSHIP OF p53 GENE MUTATION AND TUMORINVASION AND LYMPH NODE METASTASIS IN EARLY GASTRIC CANCER |
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| Xu Wei,Che Xiangming,Shunichi Hokita,Sonshin Takao.THE RELATIONSHIP OF p53 GENE MUTATION AND TUMORINVASION AND LYMPH NODE METASTASIS IN EARLY GASTRIC CANCER[J].Academic Journal of Xi’an Jiaotong University,1998(1). |
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| Authors: | Xu Wei Che Xiangming Shunichi Hokita Sonshin Takao |
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| Abstract: | This study was conducted by determination or mutative p53 gene expression in 32 casesof submucosa early gastric cancer. The relationship of p53 gene mutation and tumorlgenesis andprogress or gastric cancer was evaluated based on the cllnlco-pathological characteristics of early gastric cancer. Results showed that positive rate or P53 Protein expression was 34. 8% in early gastriccancer and p53 mutation related to the hlstology, location or tumor and lymph node metastasis (P <0. 05). Our research suggested that p53 gene ed,resslon closely related to the prognosis of early gastric cancer, and carcinogenesls I,athways may be different according to the positions of stomach. |
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| Keywords: | p53 gene early gastric cancer pathology lymph node metastasis |
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