| A STUDY ON LIMITATION OF HIGH-ENERGY SHOCK WAVE-INDUCED RENAL DAMAGE BY SALVIA MILTIORRHIZAE INJECTION IN RABBIT MODEL |
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| 作者姓名： | 陈兴发 盛斌武 贺大林 |
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| 作者单位： | Department of Urology，Department of Urology，Department of Urology First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China |
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| 基金项目： | TheworkissupportbythekeyitemofScitechnicalDevelopmentFoundationofShaanxiProvince(No.2001K11G7) |
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| 摘 要： | Extracorpealshockwavelithotripsy (ESWL)isanoninvasive ,almostpain freestandardtreatmentmodalityforurolithiasis.However ,ESWLisnotcompletelyfreeofsideeffect.Apartfromlocalhematomasanda potentialriskforhypertensionchanges,alterationsinkidneyfunctionhavebeenreported .SalviaMiltiorrhizaehasthe propertyofpromotingbloodcirculationandresolvingbloodsta sis.Thisstudywasinitiatedtoinvestigatethepo tentialprotectivefunctionofSalviaMiltiorrhizaeeagainsthigh energyshockwaveinducedrenaltoxi city .MATE…
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| 关 键 词： | 肾损伤 高能冲击波诱导 草药 动物实验 |
A STUDY ON LIMITATION OF HIGH-ENERGY SHOCK WAVE-INDUCED RENAL DAMAGE BY SALVIA MILTIORRHIZAE INJECTION IN RABBIT MODEL |
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| Chen Xingfa,Sheng Binwu,He Dalin.A STUDY ON LIMITATION OF HIGH-ENERGY SHOCK WAVE-INDUCED RENAL DAMAGE BY SALVIA MILTIORRHIZAE INJECTION IN RABBIT MODEL[J].Academic Journal of Xi’an Jiaotong University,2004,16(1):78-81. |
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| Authors: | Chen Xingfa Sheng Binwu He Dalin |
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| Institution: | Department of Urology , First Hospital of Xi'an Jiaotong University, Xi'an 710061, China |
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| Abstract: | Objective To study the protective function of Salvia Miltiorrhizae on high-energy shockwaves (HESW) induced renal damage. Methods Thirty healthy New Zealand adult male white rabbits were randomly divided into Salvia Miltiorrhizae group and control group with 15 in each. Three days before extracorpeal shock wave lithotripsy (ESWL) the two groups were injected Salvia Miltiorrhizae and physiological saline respectively. Plasma endothelin-1 (ET-1), Superoxide dismutase (SOD) and malondialdehyde (MDA) were determined and renal morphology was observed. Results After ESWL, levels of ET-1 and MDA increased significantly, the activity of SOD decreased significantly compared with those before ESWL in control group (P< 0.05, respectively); the Salvia Miltiorrhizae treated group showed a much increase in ET-1 and MDA (P< 0.05, respectively), which kept no more than a week. And MDA in Salvia Miltiorrhizae group was not statistically significant as compared with the pre-shocking's (P> 0.05). After shocking, SOD, related to renal protection, in Salvia Miltiorrhizae group was significantly higher than that of controls (P< 0.05). Renal morphological injury was slight in Salvia Miltiorrhizae group. Conclusion Salvia Miltiorrhizae injection has protective function on renal toxicity induced by high-energy shock waves. |
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| Keywords: | extracorpeal shock wave lithotripsy kidney damage herbs |
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